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Isaac Cheat Sheet

Rebirth Items

  • <3

    ItemID: 15

    "HP up"

    • +1 Health Up

    • Fully restores all red heart containers

      Type: Passive

      Item Pool: Item Room, Boss Room

    * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool

  • ???'s Only Friend

    ItemID: 320

    "Controlled friend"

    • A familiar fly that can be moved around via use of the arrow keys dealing contact damage, similar to the Ludovico Technique's mechanic.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

    UNLOCK: Unlock this item by beating Boss Rush with Blue Baby.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool, blue fly, big fly, blue baby's only friend

  • 1UP

    ItemID: 11

    "Extra life"

    • Gives the player an extra life

    • When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health.

    • Resurrection takes place before all other items which give you an extra live, except Guppy's Collar.

      Type: Passive

      Item Pool: Secret Room

    * secret room pool, mario, green mushroom, extra life

  • 20/20

    ItemID: 245

    "Double shot"

    • Isaac now shoots from both eyes at the same time.

    • Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, effectively giving you double damage per second potential.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * 20 20, item room, treasure room, item room pool, black glasses, spectacles

  • 3 Dollar Bill

    ItemID: 191

    "Rainbow tears"

    • Random tear effect for every room.

    • Possible tear effects: Fire Mind, Spoon Bender, My Reflection, Ouija Board, 20/20, Inner Eye, Iron Bar, Death's Touch, Scorpio, Tough Love, Proptosis, Number One, Mom's Contacts, Ball of Tar, Dark Matter, Speed Ball or Sagittarius.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool, pink note, money, cash,

  • 9 Volt

    ItemID: 116

    "Quicker charge"

    • Automatically gives you 1 bar of charge after using your spacebar item.

    • Fully recharges your current spacebar item when picked up.

    • Causes the Sharp Plug item to become useless due to the fact that you can never have 0 charge on your spacebar item.

    • Any items which are normally a 1 room recharge are now timed instead.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool, battery, black, brown,

  • Abaddon

    ItemID: 230

    "Evil up + DMG up + fear shot"

    • On pickup removes all of your red hearts and gives you 6 black hearts.

    • +1.5 Damage Up.

    • +0.2 Speed Up.

    • Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period.

    • The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

    UNLOCK: Unlock this item by beating the Chest with Azazel.

      Type: Passive

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal, red devil sign, abandon, abadon

  • Abel

    ItemID: 188

    "Mirrored buddy"

    • A familiar that mirrors the player's movements and shoots tears in the opposite direction.

    • Abel's tears do the same as Isaac's base damage (3.5).

    • In larger rooms, Abel will mirror to the other side of the screen instead of the entire room.

    UNLOCK: Unlock this item by beating the Dark Room with Cain.

      Type: Passive, Familiar

      Item Pool: Item Room, Gold Chest

    * golden chest pool, gold chest pool, item room, treasure room, item room pool, follower, everyone knows it's abel, brown, grey, gray,

  • Anarchist's Cookbook

    ItemID: 65

    "Summon bombs"

    • Spawns troll bombs at random locations around the room.

    • Bombs are effected by other passive bomb items.

      Type: Active

      Recharge Time: 3 rooms.

      Item Pool: Item Room, Library

    * library pool, library room, book room pool, item room, treasure room, item room pool, white, red

  • Anemic

    ItemID: 214

    "Toxic blood"

    • +5 Range Up.

    • When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room.

    • Lazarus' revived form (Lazarus II) respawns with this item.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, blood drop, red blood

  • Ankh

    ItemID: 161

    "Eternal life?"

    • Upon death, the player respawns as Blue Baby with three Soul hearts.

    • This is a one time use item and all new heart containers will be soul hearts.

    • Can be used to unlock some of Blue Baby's secrets before having the character available.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, black, grey, gray, extra life

  • Anti-Gravity

    ItemID: 222

    "Antigravity tears + tears up"

    • +0.32 Tears Up.

    • As you hold down the fire button, shots will float in the same place until you release the fire key again.

    • Allows you to store up a lot of tears in the air and release them all at once.

    • When the tears are released, they will fire off in the direction that Isaac was originally facing when it was created.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * anti gravity, item room, treasure room, item room pool, anti gravity,

  • Aquarius

    ItemID: 308

    "A trail of tears"

    • Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan

  • Aries

    ItemID: 300

    "Ramming speed"

    • +0.25 Speed up.

    • Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed.

    • Will not deal contact damage unless you are moving fast enough.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan

  • Ball of Bandages

    ItemID: 207

    "Gotta lick em all"

    • Gives Isaac an orbital ball of bandages that blocks shots, very similar to the Cube of Meat.

    • Collecting a second Ball of Bandages in the run turns the orbital into a pink head that shoots tears which have a chance to charm enemies.

    • Getting a third Ball of Bandages will transform the head into bandage girl which will chase enemies while firing charm tears.

    • A fourth Ball of Bandages will make the Bandage Girl bigger and stronger, making her deal more damage.

    • Any further Ball of Bandages will repeat the cycle.

    • Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac.

    • Has a chance to drop from one of the Horsemen bosses and can be received from using Monster Manual.

      Type: Passive, Orbital

      Item Pool: None (Horsemen boss only)

    * super meat boy

  • Ball of Tar

    ItemID: 231

    "Sticky feet..."

    • Isaac leaves a trail of tar behind him which will slow down enemies that walk over it.

    • Tears have a chance to slow enemies and their projectiles for a short period of time.

    • The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, black,

  • The Battery

    ItemID: 63

    "Stores energy"

    • All spacebar items can now be 'overcharged', allowing them to be charged up twice instead of once.

    • The extra charges appear in yellow on top of the normal green bars.

    • Has no effect with items which recharge over time instead of on a per-room basis.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • BBF

    ItemID: 272

    "Big beautiful fly"

    • A large familiar black fly that bounces around the room, exploding on contact with enemies dealing 70 damage.

    • Does not explode if it hits Isaac, however if it explodes on an enemy while Isaac is in range, he will take damage.

    • Respawns after 10 seconds or by moving to another room.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool,

  • The Bean

    ItemID: 111

    "Toot on command"

    • Upon use, this item causes Isaac to fart and poison any enemies in close proximity.

    • The Bean deals 26 damage total (5 initially then 21 in a Damage over Time effect.

      Type: Active

      Recharge Time: 1 room.

      Item Pool: Item Room, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, team bean, #teambean

  • The Belt

    ItemID: 28

    "Speed up"

    • +0.3 Speed Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Best Bud

    ItemID: 274

    "Sworn protector"

    • When Isaac takes damage, a white attack fly will spawn that orbits him at a similar distance to the Distant Admiration fly.

    • The fly orbits a lot faster than Distant Admiration or Forever Alone.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Orbital

      Item Pool: Item Room, Key Beggar

    * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, the lost item pool

  • Best Friend

    ItemID: 136

    "Friends 'till the end"

    • Places a decoy on the floor which attracts enemies and explodes after a period of time.

    • When it explodes, it deals 110 damage to everything in radius (Same damage as Mr Mega bombs).

      Type: Active

      Recharge Time: 3 rooms.

      Item Pool: Item Room

    * item room, treasure room, item room pool, worst friend

  • BFFS!

    ItemID: 247

    "Your friends rule!"

    • Makes all of Isaac's familiars much bigger, making them deal more damage.

    • Causes all familiars to deal double damage (x2 / +100%).

    • Has no effect on Rotten Baby, which instead benefits from Hive Mind.

      Type: Passive

      Item Pool: Shop, Key Beggar

    * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, northernlion

  • The Bible

    ItemID: 33

    "Temporary flight"

    • Gives Isaac angel wings for the current room, allowing him to fly.

    • If used during the Mom's Foot or Mom's Heart boss fights, The Bible will kill Mom instantly.

    • If used during the Satan boss fight, The Bible will instantly kill Isaac.

      Type: Active

      Recharge Time: 6 rooms.

      Item Pool: Shop, Library, Angel Room

    * library pool, library room, book room pool, angel room pool, god room pool, angel room item, shop room pool, shop item pool,

  • Big Fan

    ItemID: 279

    "Fat protector"

    • A very large orbital that moves around Isaac very slowly, blocking shots and dealing contact damage.

    • Affects the speed of all other orbitals, slowing them down a lot.

    • Does not count as one of your three standard orbitals, allowing you to have a total of 4.

    • Can block and prevent damage from Brimstone lasers.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Orbital

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Black Bean

    ItemID: 180

    "Toot on touch"

    • Upon taking damage, Isaac will fart, causing all enemies in close proximity to become poisoned.

    • Black Bean deals 26 damage total (5 initially then 21 in a Damage over Time effect.

      Type: Passive

      Item Pool: Item Room, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, the lost item pool

  • Black Candle

    ItemID: 260

    "Curse of immunity + evil up"

    • +1 Black Heart.

    • Immunity to all floor curses (e.g. Curse of the Lost)

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

    • An item that can appear in the shop room or in a Curse Room.

    • Higher chance of a Devil Deal opening after the boss fight (Approximately +25% through testing).

    UNLOCK: Unlock this item by donating 150 pennies to the Shop.

      Type: Passive

      Item Pool: Shop, Curse Room

    * curse room pool, shop room pool, shop item pool,

  • Black Lotus

    ItemID: 226

    "HP up x3"

    • +1 Health Up.

    • +1 Soul Heart.

    • +1 Black Heart.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

    • An item only found in the secret room pool.

      Type: Passive

      Item Pool: Secret Room

    * secret room pool, , the lost item pool

  • Blank Card

    ItemID: 286

    "Card Mimic"

    • When used, copies the effect of the tarot card you are currently holding.

    • The Blank Card can also be used to mimic mystic runes as well as tarot cards.

    • An item that often appears in the shop.

    UNLOCK: Unlock this item by beating the Isaac boss with Eden.

      Type: Active

      Recharge Time: 4 rooms.

      Item Pool: Item Room, Shop, Secret Room

    * secret room pool, shop room pool, shop item pool, item room, treasure room, item room pool

  • Blood Bag

    ItemID: 119

    "HP up"

    • +1 Health Up

    • Heals for 5 full red hearts.

    • Unlike the original game, this item is NOT a Speed Up.

    • Has a chance to drop while playing any Blood Donation machine.

    UNLOCK: Unlock this item by playing the Blood Donation machine 30 times.

      Type: Passive

      Item Pool: None (Blood Donation machine only)

    * , the lost item pool

  • Blood Clot

    ItemID: 254

    "DMG + range up"

    • +1.0 Damage Up.

    • +5 Range Up.

    • The above stats only apply to tears fired from Isaac's left eye or with a 50% chance if you have an item which causes you to fire from a single source only.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Blood of the Martyr

    ItemID: 7

    "DMG up"

    • +1.0 Damage Up.

    • 1.5x Damage Multiplier if you also have Book of Belial (Does not stack with Magic Mushroom multiplier)

    • This item can only be found in the item room pool, unlike the original game where it was also a god item

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Blood Rights

    ItemID: 186

    "Mass enemy damage at a cost"

    • Upon use, takes away one full heart and deals 40 damage to the entire room.

    • With the Isaac's Heart item, you can use Blood Rights without taking damage.

    UNLOCK: Unlock this item by beating Satan with Samson.

      Type: Active

      Recharge Time: Instant.

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Bloody Lust

    ItemID: 157

    "RAGE!"

    • Each time you take damage, you gain a damage up which lasts for the rest of the floor and turn a darker red colour each time.

    • After taking 6 hits you will cap at +6.5 Damage for the rest of the floor.

    • Damage given for each hit increases as follows: +0.5, +0.5, +0.5, +1.66, +1.66, +1.66.

    • Bloody lust works differently in Rebirth - Damage is given for taking damage and is persistent for the entire floor.

    UNLOCK: Unlock this item by beating the Isaac boss with Samson.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Blue Cap

    ItemID: 342

    "HP + tears + shot speed down"

    • +1 Health Up.

    • +0.7 Tears Up.

    • -0.16 Shot Speed Down.

    • An item only found in the Boss Room pool.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, mushroom, fungi, fungus,

  • Blue Map

    ItemID: 246

    "Secrets"

    • Reveals the locations of the secret and super secret room for the current floor and all future floors.

    UNLOCK: Unlock this item by donating 10 pennies to the Shop.

      Type: Passive

      Item Pool: Shop, Beggar, Key Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool,

  • Bob's Brain

    ItemID: 273

    "Explosive thoughts"

    • A green brain that launches in the direction you are firing your tears and will explode on contact with enemies, dealing damage and poisoning anything in the blast radius.

    • Bob's Brain can deal anywhere between 67.5 - 69.5 damage and this will scale with further bomb upgrade items.

    • Regenerates over time.

    • Will hurt Isaac if he is in the blast radius.

      Type: Passive, Familiar

      Item Pool: Item Room, Gold Chest

    * golden chest pool, gold chest pool, item room, treasure room, item room pool

  • Bob's Curse

    ItemID: 140

    "Poison bombs"

    • All of Isaac's bombs now leave a poison effect on any enemies within the blast radius.

    • +5 Bombs.

    • As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick.

      Type: Passive

      Item Pool: Item Room

    * boss rush pool, boss rush room, item room, treasure room, item room pool, bob sloth

  • Bob's Rotten Head

    ItemID: 42

    "Reusable ranged bomb"

    • A poison bomb which can be thrown and leaves a poison effect on any enemies within the blast radius.

    • The bomb deals 50 damage on hit and leaves a damage over time poison effect that does 6 or 8 damage per tick.

    • Synergizes with tear modifying items such as My Reflection or Tiny Planet.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room, Gold Chest

    * golden chest pool, gold chest pool, item room, treasure room, item room pool, bob sloth

  • Bobby - Bomb

    ItemID: 125

    "Friends till the end"

    • All of Isaac's bombs now having a homing effect when placed on the floor.

    • +5 Bombs.

      Type: Passive

      Item Pool: Item Room

    * boss rush pool, boss rush room, item room, treasure room, item room pool

  • The Body

    ItemID: 334

    "I feel all"

    • +3 Health Up.

    • The three heart containers are pre-filled with red hearts.

    UNLOCK: Unlock this item by beating the Chest with The Lost.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, real platinum god, the lost item pool

  • Bogo Bombs

    ItemID: 250

    "1+1 bombs"

    • All bomb pickups are now 1+1 bombs.

    • An item only found in the Shop item pool.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Bomb Bag

    ItemID: 131

    "Gives bombs"

    • A bag of bombs that will drop a bomb pickup every 2 rooms.

    UNLOCK: Unlock this item by beating Satan with Cain.

      Type: Passive, Familiar

      Item Pool: Item Room, Secret Room

    * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool

  • The Book of Belial

    ItemID: 34

    "Temporary DMG up"

    • Upon use, gives +2 damage up which lasts for the current room.

    • 1.5x Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom multiplier).

    • Guaranteed Devil or Angel Room if you have it when you kill the boss on all floors where it's possible to get one.

    • Judas starts with this item.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Library, Devil Room

    * library pool, library room, book room pool, devil pool, devil room pool, devil deal

  • Book of Revelations

    ItemID: 78

    "Reusable soul protection"

    • Upon use, gives Isaac an extra Soul heart.

    • Using this item gives you a higher chance of finding a horsemen boss at the end of the floor.

    • Higher chance of a Devil Deal opening after the boss fight (Exact chance unknown).

    UNLOCK: Unlock this item by beating one of the horsemen bosses for the first time.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room, Library

    * library pool, library room, book room pool, item room, treasure room, item room pool, the lost item pool

  • Book of Secrets

    ItemID: 287

    "??????"

    • When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations)

    UNLOCK: Unlock this item by beating Satan with Eden.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room, Library, Secret Room

    * library pool, library room, book room pool, secret room pool, item room, treasure room, item room pool, question mark book

  • Book of Shadows

    ItemID: 58

    "Temporary invincibility"

    • Gives the player an invulnerability effect which lasts for a few seconds.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room, Library

    * library pool, library room, book room pool, item room, treasure room, item room pool

  • The Book of Sin

    ItemID: 97

    "Reusable item generator"

    • Spawns a random pickup on the floor.

    • The possible pickups from this item include: Bombs, hearts, keys, coins, pills, batteries or tarot cards.

    UNLOCK: Unlock this item by beating each of the Seven Sins once.

      Type: Active

      Recharge Time: 4 rooms

      Item Pool: Item Room, Library, Devil Room

    * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red 7 book

  • Boom!

    ItemID: 19

    "10 bombs"

    • +10 Bombs

      Type: Passive

      Item Pool: Item Room

    * boss rush pool, boss rush room, item room, treasure room, item room pool

  • Boomerang

    ItemID: 338

    "It will never leave you"

    • A blue boomerang which can be thrown in a similar fashion to Mom's Knife, to stun any enemies it hits and deal damage.

    • The damage dealt by the Boomerang is equal to double your tear damage.

    • The boomerang can also be used to grab pickups and consumables from a distance, similar to the legend of zelda boomerang.

    • The range of the boomerang is affected by range, with number one the distance is very short and makes the item a lot less effective.

      Type: Active

      Recharge Time: Timed (A few seconds)

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Box

    ItemID: 198

    "Stuff"

    • Spawns one of each type of pickup.

    • Pickups spawned: 1 heart, 1 key, 1 bomb, 1 coin, 1 card, 1 pill and 1 trinket.

      Type: Passive

      Item Pool: Boss Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item,

  • Box of Spiders

    ItemID: 288

    "It's a box of spiders"

    • When used, spawns 2-4 friendly blue spiders on the floor.

    • Blue Spiders do 2.5x of Isaac's damage.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Breakfast

    ItemID: 25

    "HP up"

    • +1 Health Up.

      Type: Passive

      Item Pool: Boss Room, Challenge Room, Beggar

    * dungeon room, challenge room pool, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool

  • Breath of Life

    ItemID: 326

    "Invincibility at a cost"

    • While you hold the spacebar down with this item, it will de-charge gradually and when the charge bar gets to zero it will grant you a brief period of invincibility.

    • If the spacebar is held for too long (about 1 second) when it has no charge, you will take damage.

      Type: Active

      Recharge Time: Timed (1 bar per second)

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item

  • Brimstone

    Special item

    ItemID: 118

    "Blood laser barrage"

    • Tears are replaced with the ability to charge and fire a powerful laser that travels in a straight line across the room, dealing a lot of damage (damage * 13) to any enemies it comes into contact with.

    • Does not directly affect your Damage stat but hits enemies 13 times per charge.

    • Synergizes very well with a lot of items including Tammy's Head, Tiny Planet, Inner Eye (Triple Shot), Mutant Spider (Quad Shot) and many others.

    • An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool)

      Type: Passive, Tear Modifier

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal

  • Broken Watch

    ItemID: 337

    "I think its broken"

    • Upon entering a new room, you now have a chance to randomly slow down or speed up all enemies in the room.

    • An item only found in the Shop item pool.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Brother Bobby

    ItemID: 8

    "Friends 'till the end"

    • A familiar which follows Isaac and shoots normal tears which do 3.5 damage.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * item room, treasure room, item room pool, devil pool, devil room pool, devil deal

  • Bucket of Lard

    ItemID: 129

    "HP up"

    • +2 Health Up.

    • -0.2 Speed Down.

    • Of the two heart containers given from this item, only 1/2 a red heart of them is filled.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Bum Friend

    ItemID: 144

    "He's Greedy"

    • A beggar who follows Isaac around and automatically picks up nearby coins. After picking up a coin he has a random chance to drop pickups, including hearts, keys, bombs, coins, pills, cards or trinkets.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Butt Bombs

    ItemID: 209

    "Toxic blast +5 bombs"

    • +5 bombs.

    • Bombs now become poop bombs, which deal 10 damage to all enemies in the room and daze them for a short period of time.

      Type: Passive

      Item Pool: Item Room

    * boss rush pool, boss rush room, item room, treasure room, item room pool

  • Butter Bean

    ItemID: 294

    "Reusable knockback"

    • When used, farts on nearby enemies and knocks them backwards away from Isaac.

    UNLOCK: Unlock this item by destroying 100 poops.

      Type: Active

      Recharge Time: Timed (A few seconds)

      Item Pool: Item Room, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool

  • Caffeine Pill

    ItemID: 340

    "Speed up + size down"

    • +0.3 Speed Up.

    • Player Size Down.

    • Gives you a random pill when picked up.

    • An item only found in the boss room pool.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, pro plus

  • Cain's Other Eye

    ItemID: 319

    "Near sighted friend"

    • A familiar eye that bounces around the room slowly and fires tears in the same direction as Isaac.

    • Cain's Other Eye deals 3.5 damage per tear (The same as Isaac's base damage).

    UNLOCK: Unlock this item by beating Boss Rush with Cain.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool, eyeball

  • Cancer

    ItemID: 301

    "HP up + you feel protected"

    • +3 Soul Hearts

    • After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken).

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool, cyan, black, the lost item pool

  • The Candle

    ItemID: 164

    "Reusable flame"

    • A spacebar item which allows Isaac to fire a blue flame that damages anything in its path for 23 damage per tick.

    • Can cause up to a total of 184 potential damage.

    UNLOCK: Unlock this item by donating 900 coins to the Shop.

      Type: Active

      Recharge Time: Timed (A few seconds)

      Item Pool: Shop

    * shop room pool, shop item pool, blue candle,

  • Capricorn

    ItemID: 307

    "All stats up"

    • +1 Health Up.

    • +0.5 Damage Up.

    • +0.16 Tears up.

    • +0.1 Speed Up.

    • +1.5 Range Up.

    • +1 Key, +1 Bomb, +1 Coin.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool, cyan, black,

  • Cat-O-Nine-Tails

    ItemID: 165

    "Shot speed up + DMG up"

    • +1.0 Damage Up.

    • +0.23 Shot Speed Up.

    • An item only found in the Boss room pool.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Celtic Cross

    ItemID: 162

    "You feel blessed"

    • Upon taking damage, you have a chance to gain an invulnerability shield for a few seconds.

    • The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time.

    UNLOCK: Unlock this item by beating the Chest with Maggy.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Ceremonial Robes

    ItemID: 216

    "Sin up"

    • +3 Black Hearts.

    • +1 Damage Up.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

      Type: Passive

      Item Pool: Devil Room, Curse Room, Demon Beggar

    * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, devil room pool, devil deal

  • Champion Belt

    ItemID: 208

    "DMG + Challenge up"

    • +1.0 Damage Up.

    • Increases the chance of champion enemies appearing.

    • An item only found in the Shop room pool.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Charm of the Vampire

    ItemID: 62

    "Kills heal"

    • Heals half a heart after every few enemies killed.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Chemical Peel

    ItemID: 154

    "DMG up"

    • +2 Damage Up for tears fired from Isaac's left eye.

    • If you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Chocolate Milk

    ItemID: 69

    "Charge shots"

    • Isaac can now charge shots for more damage by holding down the fire button.

    • At full charge, your tears do 4 times more damage.

    • Tears up - Spamming the fire button allows for rapid fire shots at normal damage.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Common Cold

    ItemID: 103

    "Poison damage"

    • Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies.

    • The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time.

    • Gives a big increase in damage to Dr. Fetus bombs.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Compass

    ItemID: 21

    "The end is near"

    • Shows all icons on the map (e.g. Shop)

    • Does not show the layout of the map.

    • Room icons will not show if a curse of the blind is in effect on the current floor.

      Type: Passive

      Item Pool: Shop, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool,

  • Contract From Below

    ItemID: 241

    "Wealth, but at what cost?"

    • Doubles your pickup drops including chests, soul hearts and all other consumables which spawn at the end of a room.

    • Higher chance for 'double trouble' rooms (2 bosses at once).

      Type: Passive

      Item Pool: Devil Room, Curse Room, Demon Beggar

    * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, devil room pool, devil deal

  • Converter

    ItemID: 296

    "Convert your soul"

    • When used, converts 2 soul or black hearts into 1 red heart container.

    • This item will take from your soul hearts first.

      Type: Active

      Recharge Time: Instant

      Item Pool: Shop

    * shop room pool, shop item pool, the lost item pool

  • Crack The Sky

    ItemID: 160

    "Holy white death"

    • Creates 5 beams of light at random locations in the room, dealing 20 damage to any enemies which come into contact with them.

    • The beams tend to favour spawning in the middle of the room but also have a chance to spawn infront of an enemy.

      Type: Active

      Recharge Time: 4 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Cricket's Body

    ItemID: 224

    "Splash damage + tears up"

    • +0.16 Tears Up.

    • -10.0 Range Down.

    • Makes tears break into 4 smaller tears on impact with anything which deal half of your damage.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Cricket's Head

    ItemID: 4

    "DMG up"

    • +0.5 Damage Up

    • x1.5 Damage Multiplier.

    • Tears now have a significant knockback effect (Does not increase the shot speed stat).

    • Can be found in golden chests.

    • Cricket's Head used to be known as 'Max's Head in the original game and was renamed for Rebirth.

      Type: Passive

      Item Pool: Item Room, Gold Chest

    * item room, treasure room, item room pool, golden chest pool, gold chest pool,

  • Crystal Ball

    ItemID: 158

    "I see my future"

    • Upon use, reveals the entire map and gives the player a random tarot card, mystic rune or soul heart.

    • Has a chance to drop from playing a fortune machine.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Cube of Meat

    ItemID: 73

    "Gotta meat em all"

    • An orbital which blocks shots and damages enemies it comes into contact with for 7 damage per tick.

    • Exclusively drops from one of the horsemen bosses.

    • 2 cubes of meat transform the orbital into a meat head which fires blood tears.

    • 3 cubes of meat transform it into a meat boy familiar that walks around and deals contact damage to enemies.

    • 4 cubes of meat cause the meat boy familiar to grow in size and do more damage.

    • Any further cubes of meat past 4 will start the cycle again.

    UNLOCK: Unlock this item by beating Mom for the first time.

      Type: Passive

      Item Pool: None (Horsemen boss only)

    *

  • Cupid's Arrow

    ItemID: 48

    "Piercing shots"

    • Isaac's tears now have a piercing effect which allows them to travel through enemies whilst damaging them.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, arrow, penetrative, penetrating shots

  • Cursed Eye

    ItemID: 316

    "Cursed charged shot"

    • Tears are now charged up and fired rapidly in a burst of up to 4 shots at once.

    • The amount of tears fired in the charge depends on how long you charge for.

    • The eye has three states, white (not firing), black (first second of charging) and blinking between black and white. If you get hit while Cursed eye is a solid black colour you are guaranteed to be teleported to another random room on the floor. If you get hit in either of the other 2 states you will not be teleported.

      Type: Passive, Tear Modifier

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • D4

    ItemID: 284

    "Reroll into something else"

    • When used, the D4 re-rolls your items into another item from the same pool.

    • Each time an item is generated by the D4, it is also removed from the pool. When the pool is empty, it will eventually re-roll all your items into heart containers.

    • Cannot remove Azazel's Brimstone laser.

    UNLOCK: Unlock this item by blowing up 30 slot machines.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, dice

  • D10

    ItemID: 285

    "Rerolls enemies"

    • When used, rerolls all enemies in the room which are currently alive into another random type of enemy from any floor.

    • Dangerous to use in early floors, it could replace a basement enemy with something usually found in the Womb only.

    • Cannot reroll mini-bosses or bosses.

      Type: Active

      Recharge Time: 1 room

      Item Pool: Item Room

    * item room, treasure room, item room pool, DIO, dice

  • D100

    Special item

    ItemID: 283

    "REEROLLLLL!"

    • When used, rerolls all items you currently own and any pedestal items and pickups in the room.

    • Has the combined uses of the D4, D6 and D20.

    UNLOCK: Unlock this item by beating Boss Rush with The Lost.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, deathstar, death star, dice

  • D20

    ItemID: 166

    "Reroll the basics"

    • Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup.

    • This includes hearts, bombs, keys, coins, pills, tarot cards, chests and trinkets.

    UNLOCK: Unlock this item by beating the Chest with Isaac.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, dice

  • The D6

    Special item

    ItemID: 105

    "Reroll your destiny"

    • Upon use, any pedestal item (e.g. an item room item) will be re-rolled into another item.

    UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, dice

  • Dad's Key

    ItemID: 175

    "Opens all doors..."

    • Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors.

    • Can be used to open the golden door that appears in the Dark Room or the Chest.

    UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room, Key Beggar

    * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool

  • Daddy Longlegs

    ItemID: 170

    "Daddy's love"

    • A shadow follows Isaac and stomps on enemies randomly, dealing 40 damage per stomp.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Dark Bum

    ItemID: 278

    "He wants to take your life"

    • A familiar beggar similar to Bum Friend that follows Isaac and collects red hearts, giving Isaac soul hearts or spiders in return.

    • Soul hearts are the most common payout with only a small chance to spawn friendly or hostile spiders.

    • Dark Bum has a small chance to give a black heart instead of a soul heart.

    • For every 1.5 red hearts he takes, he will give 1 heart/spider in return.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, celebrate good times come on, the lost item pool, q t 3.14, dark bum, otp, damn it reddit

  • Dark Matter

    ItemID: 259

    "Fear shot"

    • Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac.

    • +1.0 Damage Up.

    • The chance to fear enemies is affected by your luck stat and at +20 Luck it will activate every time.

    • An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool)

      Type: Passive

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal

  • Dead Bird

    ItemID: 117

    "Protective buddy"

    • When Isaac takes damage, the dead bird will spawn and attack nearby enemies in the current room for 2 damage per tick.

    • Eve starts with this item.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Dead Cat

    ItemID: 81

    "9 lives"

    • Isaac's health is set to 1 but he also gets 8 extra lives.

    • Each time Isaac dies, he will respawn with 1 Health.

    • Has a chance to drop from the Super Pride mini boss.

    • The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost)

    • This is one of the items which allows you to transform into Guppy.

      Type: Passive

      Item Pool: Devil Room, Curse Room, Red Chest

    * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal

  • Dead Dove

    ItemID: 185

    "Flight + spectral tears"

    • Gives Isaac the ability to fly and spectral tears.

    • An item only found in the Angel room.

      Type: Passive

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item

  • Dead Onion

    ItemID: 336

    "Toxic aura tears"

    • Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral).

    • -0.25 Range Down.

    • -0.4 Shot Speed Down.

    • -0.5 Tear Height.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Dead Sea Scrolls

    ItemID: 124

    "It's a mystery"

    • Upon use, the dead sea scrolls gives a random spacebar item effect.

    • An item that can be found in the Angel room.

      Type: Active

      Recharge Time: 4 rooms

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool

  • Death's Touch

    ItemID: 237

    "Penetrative shots + DMG up"

    • +1.5 Damage Up.

    • -0.3 Tears Down.

    • Isaac's tears turn into large scythes that penetrate through enemies (Similar to how Death's scythes look).

    UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka).

      Type: Passive, Tear Modifier

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Deck of Cards

    ItemID: 85

    "Reusable card generator"

    • Gives Isaac a random tarot card on use.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room, Shop

    * shop room pool, shop item pool, item room, treasure room, item room pool

  • Demon Baby

    ItemID: 113

    "Auto-turret friend"

    • A familiar which follows Isaac and automatically fires tears that deal 3 damage each at any enemies in close range.

    UNLOCK: Unlock this item by beating the Dark Room with Azazel.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Dessert

    ItemID: 24

    "HP up"

    • +1 Health Up.

      Type: Passive

      Item Pool: Boss Room, Beggar, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool

  • Dinner

    ItemID: 23

    "HP up"

    • +1 Health Up.

      Type: Passive

      Item Pool: Boss Room, Beggar, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool

  • Distant Admiration

    ItemID: 57

    "Attack fly"

    • Gives Isaac an orbiting fly which deals 5 contact damage to enemies per tick.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Orbital

      Item Pool: Item Room, Key Beggar

    * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool

  • Doctor's Remote

    ItemID: 47

    "Reusable air strike"

    • A target is placed on the floor which can be controlled. After a few seconds a huge missile hits the target and deals 70 damage to anything nearby.

    • The damage dealt from this item scales with your damage stat.

    • Essentially a one-time more powerful use of the Epic Fetus item.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • A Dollar

    ItemID: 18

    "$$$"

    • +99 coins.

    • Can drop from an exploding slot machine while playing it.

      Type: Passive

      Item Pool: None (Arcade machine only)

    * slot machine, arcade machine

  • Dr. Fetus

    Special item

    ItemID: 52

    "???"

    • Instead of tears, Isaac now shoots bombs from his eyes, which explode dealing damage to anything nearby.

    • Bomb damage = damage * 3.

    • Tears Down (Tear delay * 2.5).

    • Poison effects (e.g. Bob's Curse) give Dr. Fetus bombs a flat +50 damage.

    • Bombs will also synergize with other bomb items and tear modifiers (not including Sad Bombs).

    UNLOCK: Unlock this item by beating Mom's Heart 9 times.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Dry Baby

    ItemID: 265

    "Immortal friend"

    • A familiar that follows Isaac and blocks any shots that hit it.

    • If a projectile is blocked by Dry Baby, he has a high chance to activate the Necronomicon effect, dealing 40 damage to the entire room.

    • The chance to activate the effect is not changed by your Luck stat.

    • Can drop while destroying skulls in the Depths and Necropolis floors.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool, dry baby is best baby,

  • E. Coli

    ItemID: 236

    "Turdy Touch"

    • E. Coli turns normal enemies into poop if they touch you.

    • Enemies can turn into poop even if they do not do contact damage, allowing you to apply the effect without taking damage.

    • Can be combined with Midas Touch to turn enemies into Golden Poop.

    • This does not work on mini-bosses and bosses.

      Type: Passive

      Item Pool: Item Room

    * e coli, item room, treasure room, item room pool,

  • Epic Fetus

    Special item

    ItemID: 168

    "On-demand air strike"

    • Tears now become missiles which deal huge damage to anything nearby.

    • Missiles damage = damage * 20.

    • This item places a controllable red target on the ground which will cause a missile to fall from the sky and hit it after a short period of time.

    UNLOCK: Unlock this item by beating Challenge #19 (The Family Man).

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool, fetus in a jar

  • Eve's Mascara

    ItemID: 310

    "Shot speed down + DMG up"

    • x2 Damage Multiplier.

    • Tears Down by exactly half (Tear delay * 2)

    • -0.5 Shot Speed Down.

    • The tears down from this item is a x2.0 multiplier after the formula, meaning it will always halve your tear rate (Unless you have Monstro's Lung or Soy Milk).

    UNLOCK: Unlock this item by beating Boss Rush with Eve.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, makeup, make up,

  • Experimental Treatment

    ItemID: 240

    "All stats up! ... and then shuffled"

    • When picked up, this item will increase or decrease each one of your stats by a random amount.

    • The flavour text for this item is slightly misleading, it is not an all stats up, however will average out as a slight increase overall.

    • All 6 stats are affected by this item, including shot speed and luck.

    • Can kill Blue Baby if it removes health.

    UNLOCK: Unlock this item by beating Mom's Heart 7 times.

      Type: Passive

      Item Pool: Item Room, Boss Room, Demon Beggar

    * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, yellow syringe, needle, injection,

  • Fanny pack

    ItemID: 204

    "Filled with goodies"

    • When Isaac is hit, there is a chance he will drop a pickup (i.e. coin, bomb, key)

      Type: Passive

      Item Pool: Shop, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, bag, satchel, backpack

  • Fate

    ItemID: 179

    "Flight eternal"

    • Gives Isaac an eternal heart and the ability to fly.

    • Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container.

    UNLOCK: Unlock this item by beating the Chest with Blue Baby.

      Type: Passive

      Item Pool: Gold Chest

    * golden chest pool, gold chest pool, blue head, the lost item pool

  • Fire Mind

    ItemID: 257

    "Flaming tears"

    • Isaac's tears now set enemies on fire, leaving a damage over time effect that does 4 or 6 damage per tick.

    • There is a chance that tears that hit enemies will explode, leaving a small fire on the floor that damages enemies.

    • Exploding tears deal damage * 2 + 22.

    • The chance for tears to explode is affected by your luck stat and at +13 Luck it will activate every time.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • FLUSH!

    ItemID: 291

    "..."

    • When used, turns every normal enemy in the room into poop!

    • Does not work on mini-bosses and bosses.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, silver spoon handle

  • Forever Alone

    ItemID: 128

    "Attack fly"

    • An orbiting fly which deals 2 contact damage per tick to enemies.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Orbital

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Forget Me Now

    ItemID: 127

    "I don't remember..."

    • Upon use, this item refreshes the current floor with brand new rooms, monsters and items.

    UNLOCK: Unlock this item by beating Satan with Blue Baby.

      Type: Active

      Recharge Time: Instant (One time use)

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool, pill, tablet, drug

  • The Gamekid

    ItemID: 93

    "Temporary Man-Pac"

    • When used Isaac transforms into pacman, which makes him invincible and does 40 contact damage to enemies per chomp.

    • Everytime you 'eat' an enemy, you regain some health.

    UNLOCK: Unlock this item by visiting 10 arcades.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Gemini

    ItemID: 318

    "Conjoined friend"

    • A familar that is attached to Isaac, which will seek out and damage any enemies close by.

    • One of the twelve zodiac items available in the game.

      Type: Passive, Familiar

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • Ghost Baby

    ItemID: 163

    "Spectral buddy"

    • A familiar which follows Isaac and shoots spectral tears that deal 3.5 damage.

    • Can drop while destroying skulls in the Depths and Necropolis floors.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Gimpy

    ItemID: 225

    "Sweet suffering"

    • When getting hit, this item has a chance to drop a soul heart or black heart.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

    • The chance to spawn a heart is affected by your luck stat and at +22 Luck it will activate 50% of the time.

    • Due to a bug, if you have more than 22 luck, Gimpy won't drop any Soul or Black hearts.

    • Enemies have a chance to drop half a heart when killed.

      Type: Passive

      Item Pool: Item Room, Devil Room, Curse Room, Demon Beggar

    * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool devil pool, devil room pool, devil deal, item room, treasure room, item room pool, gimp mask, the lost item pool

  • Gnawed Leaf

    ItemID: 210

    "Unbreakable"

    • If Isaac stands still for a second, he turns to stone, making him invincible until he moves again.

    • This item is a reference to the Tanuki suit in Super Mario 3.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, raccoon,

  • Goat Head

    ItemID: 215

    "He accepts your offering"

    • Gives Isaac a guaranteed devil or angel room on every floor they can appear, even if you have already beaten the boss and it didn't show up originally.

    • Taking the Goat Head (or any other item) in a Devil Deal significantly lowers your chance for Angel Rooms in the future.

      Type: Passive

      Item Pool: Devil Room, Curse Room, Red Chest, Golden Chest

    * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal

  • GodHead

    Special item

    ItemID: 331

    "God tears"

    • Isaac's tears become homing and have a large aura around them, which will deal a lot of damage to anything inside its radius.

    • +0.5 Damage Up.

    • +1.2 Range Up.

    • -0.2 Tears Down.

    • -0.3 Shot Speed Down

    • +0.8 Tear Height.

    UNLOCK: Unlock this item by beating all bosses and the Boss Rush in Hard Mode with The Lost character.

      Type: Passive, Tear Modifier

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item

  • Growth Hormones

    ItemID: 70

    "DMG up + speed up"

    • +1.0 Damage Up

    • +0.4 Speed Up

      Type: Passive

      Item Pool: Boss Room, Demon Beggar

    * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, syringe, needle, injection,

  • Guardian Angel

    ItemID: 112

    "Extra protection"

    • An orbital which does 7 contact damage per tick, blocks shots and increases the speed of all other orbitals.

    UNLOCK: Unlock this item by beating Satan with Maggy.

      Type: Passive, Orbital

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item

  • The Guillotine

    ItemID: 206

    "An out-of-body experience"

    • +1.0 Damage Up.

    • +0.16 Tears Up.

    • Causes Isaac's head to detach and orbit his body, blocking shots.

    • Tears are still fired from Isaac's head but the hitbox remains around his body.

    UNLOCK: Unlock this item by beating the Isaac boss with Judas.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Guppy's Collar

    ItemID: 212

    "Eternal life?"

    • When Isaac dies, he has a 50% chance to respawn with 1/2 a heart.

    • This is one of the items which allows you to transform into Guppy.

      Type: Passive

      Item Pool: Devil Room, Curse Room, Red Chest

    * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal

  • Guppy's Hairball

    ItemID: 187

    "Swing it"

    • Follows behind Isaac and can be swung back and forth, dealing contact damage to anything it hits.

    • Every time the hairball kills an enemy, it grows in size allowing it to deal more damage.

    • This is one of the items which allows you to transform into Guppy.

    UNLOCK: Unlock this item by collecting 3 Guppy items and transforming into Guppy.

      Type: Passive, Familiar

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal

  • Guppy's Head

    ItemID: 145

    "Reusable fly hive"

    • When used, spawns between 2-4 blue flies.

    • This is one of the items which allows you to transform into Guppy.

    • Blue Flies do 2.0x of Isaac's damage.

      Type: Active

      Recharge Time: 1 room

      Item Pool: Devil Room, Curse Room, Red Chest, Gold Chest

    * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal

  • Guppy's Paw

    ItemID: 133

    "Soul converter"

    • When used, removes one heart container and gives you 3 soul hearts.

    • This is one of the items which allows you to transform into Guppy.

      Type: Active

      Recharge Time: Instant

      Item Pool: Devil Room, Curse Room, Red Chest

    * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, the lost item pool

  • Guppy's Tail

    ItemID: 134

    "Cursed?"

    • When picked up, greatly increases your chance of finding chests at the end of a room, while also reducing your chance to find consumables such as keys and bombs.

    • This is one of the items which allows you to transform into Guppy.

      Type: Passive

      Item Pool: Devil Room, Curse Room, Red Chest

    * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal

  • Habit

    ItemID: 156

    "Item martyr"

    • When you take damage, this item recharges one room's worth of charge to your spacebar item.

    • For example, with the D6 you would need to take damage 6 times to fully recharge it.

      Type: Passive

      Item Pool: Shop, Angel Room

    * angel room pool, god room pool, angel room item, shop room pool, shop item pool, the lost item pool

  • The Halo

    ItemID: 101

    "All stats up"

    • +1 Health Up.

    • +0.3 Damage Up.

    • +0.2 Tears Up.

    • +0.25 Range Up.

    • +0.3 Speed Up.

    • +0.5 Tear Height.

    UNLOCK: Unlock this item by killing Mom (Mom's Foot or Mom's Heart) using The Bible.

      Type: Passive

      Item Pool: Item Room, Boss Room, Angel Room

    * angel room pool, god room pool, angel room item, boss room pool, boss room item, item room, treasure room, item room pool

  • Halo of Flies

    ItemID: 10

    "Projectile protection"

    • Gives Isaac 2 orbital flies which block enemy shots.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Orbital

      Item Pool: Item Room, Key Beggar

    * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool,

  • Harlequin Baby

    ItemID: 167

    "Double shot buddy"

    • A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern.

    • Each of Harlequin Baby's tears deal 4 damage.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Head of Krampus

    ItemID: 293

    "Krampus rage"

    • When used, fires a 4 way brimstone laser in all cardinal directions, dealing a lot of damage to any enemies.

    • Maximum potential damage is 462 (20-21 ticks of 22 damage if the laser makes contact the whole duration)

    • Laser damage does not scale with your damage stat.

    • Has a chance to drop after you beat Krampus.

    • If you get close enough to an enemy that has a large hitbox, you can hit it with 2 of the laser beams, allowing you to deal a lot more damage.

    UNLOCK: Unlock this item by beating Krampus (Krampus is unlocked by taking 20 devil deal items).

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: None (Krampus only)

    *

  • Headless Baby

    ItemID: 269

    "Bloody friend"

    • A familiar that follows Isaac and leaves blood creep on the floor as it floats, hurting enemies that walk over it.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Hive Mind

    ItemID: 248

    "Giant spiders and flies"

    • Causes your friendly blue spiders and flies to become bigger and do 2x more damage.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

    • Allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Holy Grail

    ItemID: 184

    "Flight + HP up"

    • +1 Health Up

    • Gives Isaac the ability to fly.

      Type: Passive

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item, the lost item pool

  • Holy Mantle

    ItemID: 313

    "Holy shield"

    • Each time you enter a new room, damage is negated for the first time you get hit.

    • Can be used to go in and out of a Curse Room without taking damage.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool

  • Holy Water

    ItemID: 178

    "Splash!"

    • When Isaac takes damage, the bottle breaks and leaves a pool on the floor which deals damage to enemies which walk over it.

      Type: Passive, Familiar

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Hot Bombs

    ItemID: 256

    "Burning blast +5 bombs"

    • +5 Bombs

    • Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Hourglass

    ItemID: 66

    "Temporary enemy slowdown"

    • When used, slows down all enemies in the current room and their projectiles for a short period of time.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • How To Jump

    ItemID: 282

    "It's time you learned how"

    • When used, makes Isaac leap in the air, similar to the leaper enemies.

    • Maintains momentum if you are already moving in the same direction.

    • If you already have an item which gives you flying, this item becomes a dash effect instead.

    • Can be used in the Isaac boss fight to jump over the beams of light he spawns.

      Type: Active

      Recharge Time: Instant

      Item Pool: Item Room, Library

    * library pool, library room, book room pool, item room, treasure room, item room pool

  • Humbleing Bundle

    ItemID: 203

    "1+1free 4evar!"

    • All future pennies, keys, bombs and hearts will drop in pairs.

    • Does not work for soul hearts, nickels, dimes, cards or pills.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Infamy

    ItemID: 242

    "Damage reduction"

    • Puts a shield on Isaac's face making it so he has a high chance to not take damage to projectiles from any direction.

      Type: Passive

      Item Pool: Item Room, Gold Chest, Secret Room

    * golden chest pool, gold chest pool, secret room pool, item room, treasure room, item room pool

  • Infestation

    ItemID: 148

    "They grow inside"

    • When Isaac gets hit, a few blue flies will randomly spawn.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

    • Blue Flies do 2.0x of Isaac's damage.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Infestation 2

    ItemID: 234

    "Infestation shot"

    • Creates 1-2 friendly spiders when you kill an enemy.

    • Spiders are spawned at the location where the enemy died.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Inner Eye

    ItemID: 2

    "Triple shot"

    • Tears now shoot three at a time (Triple Shot)

    • Tears Down significantly (tears = tears * 2.1 + 3).

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Ipecac

    ItemID: 149

    "Explosive shots"

    • Isaac's tears are replaced with explosive poison bombs, which will arc upwards and explode on contact with the floor, dealing huge damage and leaving a poison effect on enemies in range.

    • Ipecac shots are given a flat +40 Damage on top of the normal 3.5 base damage.

    • Tears Down (Tear delay * 2 + 10).

    • +13.0 Tear Height.

    • Shots will damage Isaac if he is in the blast radius when they explode.

    UNLOCK: Unlock this item by beating Mom's Heart 6 times.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Iron Bar

    ItemID: 201

    "Concussive tears"

    • +0.3 Damage Up.

    • Tears now have a chance to concuss enemies, causing them to walk around dazed and confused for a short period of time.

    • The chance to concuss enemies is affected by your luck stat and at +27 Luck it will activate every time.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Isaac's Heart

    ItemID: 276

    "Protect it"

    • Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. If the heart is hit, Isaac will take damage.

    • Sharp Plug becomes useless with this item, due to how damage is prevented on Isaac's body.

    UNLOCK: Unlock this item by beating the Isaac boss with The Lost.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Isaac's Tears

    ItemID: 323

    "Collected tears"

    • A spacebar item that fires 8 of Isaac's tears in a circle around him.

    UNLOCK: Unlock this item by beating the Isaac boss with Isaac.

      Type: Active

      Recharge Time: 1 bar per tear fired

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • IV Bag

    ItemID: 135

    "Portable blood bank"

    • Upon use, the IV Bag takes half a red heart and spawns some coins (the same effect as a blood donation machine)

    • Can drop from a blood donation machine after playing it.

      Type: Active

      Recharge Time: Instant

      Item Pool: None (Blood donation machine only)

    * , the lost item pool

  • The Jar

    ItemID: 290

    "Save your life"

    • Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar.

    • Up to 4 hearts can be stored in The Jar.

    • Soul hearts and black hearts cannot be stored.

    • If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart.

      Type: Active

      Recharge Time: Instant

      Item Pool: Shop

    * shop room pool, shop item pool, the lost item pool

  • Jesus Juice

    ItemID: 197

    "Damage + range up"

    • +0.5 Damage Up.

    • +0.25 Range Up.

    • +0.5 Tear Height.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Judas' Shadow

    ItemID: 311

    "Sweet revenge"

    • When you die with this item, you respawn in the previous room as Black Judas with 2 black hearts for health.

    • Black Judas has a damage multiplier of 2.00 (double Isaac's damage) and an additional +0.1 Speed.

    • Black Judas is considered a separate character by the game, however he can be used to unlock Judas' secrets/achievements.

    UNLOCK: Unlock this item by beating Boss Rush with Judas.

      Type: Passive

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Juicy Sack

    ItemID: 266

    "Sticky babies"

    • A familiar that follows isaac around dropping white creep which slows down enemies that walk over it.

    • Spawns a familiar blue spider sometimes when you finish a room.

    • Blue Spiders do 2.5x of Isaac's damage.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Kamikaze

    ItemID: 40

    "Become the bomb!"

    • Causes an explosion near the player which takes away half a heart and does 40 damage all enemies in close proximity.

      Type: Active

      Recharge Time: Instant

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Key Piece #1

    ItemID: 238

    "???"

    • Increases your chances to find an Angel Room instead of a Devil Room.

    • First half of the key required to enter the door to the Mega Satan boss.

    • Drops from one of the angels which appear by bombing the statue in an angel room.

      Type: Passive, Familiar

      Item Pool: None (Angel statue only)

    * angel room, angels

  • Key Piece #2

    ItemID: 239

    "???"

    • Increases your chances to find an Angel Room instead of a Devil Room.

    • Second half of the key required to enter the door to the Mega Satan boss.

    • Drops from one of the angels which appear by bombing the statue in an angel room.

      Type: Passive, Familiar

      Item Pool: None (Angel statue only)

    *

  • The Ladder

    ItemID: 60

    "Building bridges"

    • Allows Isaac to walk over gaps with a width of one tile.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool, the lost item pool

  • Lazarus' Rags

    ItemID: 332

    "Eternal life?"

    • Gives Isaac an extra life on death, exactly the same as Lazarus' default respawn effect.

    • When you die with this item, you respawn in the same room with 1 heart and the Anemic item.

    • The game considers you to be a different character (Lazarus II) when this effect activates.

    UNLOCK: Unlock this item by beating the Isaac boss with Lazarus.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool

  • Leo

    ItemID: 302

    "Stompy"

    • Isaac gets a lion's mane and now has the ability to crush rocks by walking over them.

    • Crushed rocks and poop can fill holes if you walk in their direction.

    • Allows you to crush Red Poops and sometimes not take damage. However, If you also have flying you will always take damage.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • Latch Key

    ItemID: 343

    "Luck up"

    • +1 Luck Up.

    • +1 Soul Heart.

    • Spawns 2 keys on the ground.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Leech

    ItemID: 270

    "Blood sucker"

    • Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Lemon Mishap

    ItemID: 56

    "Oops..."

    • When used, drops a pool of 'lemonade' on the floor which damages any enemies that come into contact with it.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Libra

    ItemID: 304

    "You feel balanced"

    • Gives you 6 keys, 6 bombs and 6 coins.

    • Balances out your stats to bring the high and low stats closer to an average value.

    • All future stat upgrading items will now instead spread out across all other stats. For example, an item which usually gives +1 Damage would instead give a small 'all stats up'.

    • Stats effected by this item are: Damage, Tears, Range, Speed.

    • When taken with another item which gives an extreme value in a certain stat (e.g. Soy Milk) can lead to interesting synergies.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • Lil' Brimstone

    Special item

    ItemID: 275

    "Evil friend"

    • A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage.

    • A fully charged laser deals 31.5 damage.

    • A familiar found in the devil room.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Lil' Haunt

    ItemID: 277

    "Fear him"

    • A familiar ghost that follows Isaac around and chases enemies close-by, damaging them and causing a fear effect.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Little Baggy

    ItemID: 252

    "Extra pill room"

    • Allows for 2 pills to be held.

    • Drops a pill on the floor when picked up.

    • All future tarot card drops will now instead become pill drops.

    UNLOCK: Unlock this item by picking up 2 of the following items: Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Little C.H.A.D.

    ItemID: 96

    "Gives kisses"

    • A familiar which follows Isaac and drops half a red heart every 3 rooms.

    UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D.

      Type: Passive, Familiar

      Item Pool: Item Room, C.H.A.D. Boss

    * little chad, item room, treasure room, item room pool, the lost item pool

  • Little Chubby

    ItemID: 88

    "Attack buddy"

    • A familiar that follows Isaac and charges forwards, dealing rapid damage to any enemies it comes into contact with.

    UNLOCK: Unlock this item by beating the Caves II for the first time.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Little Gish

    ItemID: 99

    "Sticky friend"

    • A familiar that follows Isaac and fires black tar tears, which slow enemy movement and projectile speed for a few seconds.

    • Little Gish's tears do 3.5 damage.

    UNLOCK: Unlock this item by beating the Depths 20 times and killing the Gish boss.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Little Steven

    ItemID: 100

    "Psychic friend"

    • A familiar that follows Isaac and fires homing tears that deal 3.5 damage each.

    UNLOCK: Unlock this item by killing the Steven boss for the first time.

      Type: Passive, Familiar

      Item Pool: Item Room, Boss Room

    * boss room pool, boss room item, item room, treasure room, item room pool

  • Loki's Horns

    ItemID: 87

    "Cross tears"

    • Everytime you fire a tear, there is a chance that you will also fire three more tears in all cardinal directions.

    • The chance to fire 4-way tears is affected by your luck stat and at +7 Luck it will activate every time.

    UNLOCK: Unlock this item by beating Lokii for the first time.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Lord of the Pit

    ItemID: 82

    "Demon wings"

    • Gives Isaac demon wings and the ability to fly.

      Type: Passive

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal, the lost item pool

  • Lost Contact

    ItemID: 213

    "Shielded tears"

    • All of Isaac's tears now have a shield, allowing them to block an enemy projectile.

    • If a tear blocks something, both Isaac's and the enemies tears are destroyed.

    • -0.15 Shot Speed Down.

      Type: Passive

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • Lucky Foot

    ItemID: 46

    "Luck up"

    • +1.0 Luck Up.

    • Better chance to win while gambling.

    • Does not make all pills positive or neutral like the original game.

      Type: Passive

      Item Pool: Item Room, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool

  • The Ludovico Technique

    Special item

    ItemID: 329

    "Controlled tears"

    • You no longer shoot tears and instead now control a single large tear with the arrow keys.

    • Items which increase your tears stat will cause the tear to deal damage at a faster rate.

    • Items which increase your shot speed cause the tear to travel faster across the screen.

    • Ludo and Brimstone create a large controllable red ring of death that does massive damage to anything in its path.

    • Taking this with Mom's Knife allows you to remote control the knife around the room, dealing huge damage.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • A Lump of Coal

    ItemID: 132

    "My Xmas present"

    • Tears gain a damage up and increase in size based on the distance they travel.

      Type: Passive

      Item Pool: None (Krampus only)

    * krampus

  • Lunch

    ItemID: 22

    "HP up"

    • +1 Health Up.

      Type: Passive

      Item Pool: Boss Room, Challenge Room, Beggar

    * dungeon room, challenge room pool, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool

  • Maggy's Bow

    ItemID: 312

    "HP up + you feel healthy"

    • +1 Health Up.

    • All future red hearts now heal for double. Half hearts heal a whole heart and full hearts heal 2 red hearts.

    UNLOCK: Unlock this item by beating Boss Rush with Maggy.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Magic 8 Ball

    ItemID: 194

    "Shot speed up"

    • +0.16 Shot Speed Up.

    • Gives Isaac a random tarot card when picked up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Magic Fingers

    ItemID: 295

    "Pay to play"

    • Upon use, consumes a coin and deals damage to everything in the room.

    • Damage dealt is equal to your tear damage * 2.

      Type: Active

      Recharge Time: Instant

      Item Pool: Item Room, Shop

    * shop room pool, shop item pool, item room, treasure room, item room pool, tissue

  • Magic Mushroom

    ItemID: 12

    "All stats up!"

    • +1 Health Up.

    • +0.3 Damage Up.

    • x1.5 Damage Multiplier.

    • +5.25 Range Up.

    • +0.3 Speed Up.

    • +0.5 Tear Height.

    • Isaac grows in size.

    • Similar to the original game, the Magic Mushroom does not give a tears up despite saying 'All Stats Up'.

    • Fully restores all red heart containers.

    • Can be dropped when exploding mushrooms in the Caves/Catacombs.

      Type: Passive

      Item Pool: Item Room, Boss Room

    * boss room pool, boss room item, item room, treasure room, item room pool

  • Magic Scab

    ItemID: 253

    "HP + luck up"

    • +1 Health Up.

    • +1.0 Luck Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Magneto

    ItemID: 53

    "Item snatcher"

    • Causes pickups on the floor move towards the player.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Mark

    ItemID: 79

    "DMG up"

    • +1.0 Damage Up.

    • +0.2 Speed Up.

    • +1 Soul Heart.

      Type: Passive

      Item Pool: Curse Room, Devil Room

    * curse room pool, devil pool, devil room pool, devil deal

  • Match Book

    ItemID: 344

    "Evil up"

    • +1 Black Heart

    • +3 Bombs

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • MEAT!

    ItemID: 193

    "DMG + HP up"

    • +1 Health Up.

    • +0.3 Damage Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Midas Touch

    ItemID: 202

    "Golden touch"

    • Isaac's touch now petrifies enemies, turning them to gold for a few seconds.

    • If an enemy is killed while it is golden, it will drop between 1-4 coins.

    • Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Mind

    ItemID: 333

    "I know all"

    • Gives Isaac a full mapping effect, revealing the entire floor and locations of all secret rooms.

    UNLOCK: Unlock this item by beating Satan with The Lost.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool

  • Mini Mush

    ItemID: 71

    "Speed + range up"

    • +0.3 Speed Up

    • Decreases range stat by -4.25 but increases your tear height by 1.5, increasing your actual tear range.

    • Causes Isaac to shrink in size.

    • Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Missing No.

    ItemID: 258

    "Syntax error"

    • At the start of each floor this item rerolls all your current items, giving you a new item to over-ride each of the one you had.

    • A reference to the infamous 'Missingno' glitch from Pokemon.

    UNLOCK: Unlock this item by beating Boss Rush with Lazarus.

      Type: Passive

      Item Pool: Secret Room

    * secret room pool,

  • Missing Page 2

    ItemID: 262

    "Evil up + your enemies will pay"

    • +1 Black Heart.

    • Upon taking damage, if the total sum of Isaac's red hearts + soul hearts is under one and a half hearts, the necronomicon effect will activate, dealing 40 damage to the entire room.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

      Type: Passive

      Item Pool: Devil Room, Demon Beggar, Secret Room

    * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool

  • Mitre

    ItemID: 173

    "You feel blessed"

    • Gives Isaac a much higher chance to find soul hearts

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Mom's Bottle of Pills

    ItemID: 102

    "Reusable pill generator"

    • When used, gives Isaac a random pill.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar

    * dungeon room, challenge room pool, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool

  • Mom's Bra

    ItemID: 39

    "Mass fear"

    • When used, freezes all enemies in the current room temporarily.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, item room, treasure room, item room pool

  • Mom's Coin Purse

    ItemID: 195

    "What's all this...?"

    • Drops 4 random pills on the floor around Isaac.

      Type: Passive

      Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar

    * dungeon room, challenge room pool, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool,

  • Mom's Contacts

    ItemID: 110

    "Freeze effect"

    • Tears now have a random chance to freeze enemies in place.

    • The chance to freeze enemies is affected by your luck stat.

    • Does not give a Range stat up like it did in the original game.

    UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough.

      Type: Passive

      Item Pool: Item Room, Challenge Room

    * item room, treasure room, item room pool, dungeon room, challenge room pool, blood challenge room, arena pool

  • Mom's Eye

    ItemID: 55

    "Eye in the back of your head"

    • Isaac has a random chance to fire another tear out the back of his head.

    • The chance to fire the second tear can improve based on your luck stat and will always activate at +2 Luck.

    • Synergizes very well with a lot of items. If used with Brimstone you have a 100% chance to fire a laser out the back of your head.

      Type: Passive, Tear Modifier

      Item Pool: Item Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, item room, treasure room, item room pool

  • Mom's Eyeshadow

    ItemID: 200

    "Charm tears"

    • Tears have a random chance to charm enemies.

    • Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac.

    • The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time.

      Type: Passive

      Item Pool: Item Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, item room, treasure room, item room pool

  • Mom's Heels

    ItemID: 30

    "Range up"

    • +5.25 Range Up

    • +0.5 Tear Height.

      Type: Passive

      Item Pool: Boss Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, boss room pool, boss room item,

  • Mom's Key

    ItemID: 199

    "Less is more now +2 keys"

    • +2 Keys

    • Higher chance to get more consumable drops from chests.

      Type: Passive

      Item Pool: Shop, Challenge Room, Key Beggar

    * key master pool, key beggar pool, key judgement pool, , dungeon room, challenge room pool, blood challenge room, arena pool, shop room pool, shop item pool,

  • Mom's Knife

    Special item

    ItemID: 114

    "Stab stab stab"

    • Tears are replaced with a knife which can be charged and thrown in a boomerang style action.

    • The knife can also do damage without being thrown as a close range melee weapon.

    • When used as a melee weapon, Mom's Knife deals your tear damage * 2 per tick.

    UNLOCK: Unlock this item by beating Satan with Isaac.

      Type: Passive, Tear Modifier

      Item Pool: Item Room, Devil Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Mom's Lipstick

    ItemID: 31

    "Range up"

    • +5.25 Range Up

    • +0.5 Tear Height.

      Type: Passive

      Item Pool: Boss Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, boss room pool, boss room item,

  • Mom's Pad:

    ItemID: 41

    "Gross..."

    • When used, causes all enemies in the current room to run away from Isaac in fear for a few seconds.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room, Challenge Room

    * item room, treasure room, item room pool, dungeon room, challenge room pool, blood challenge room, arena pool

  • Mom's Perfume:

    ItemID: 228

    "Fear shot"

    • +0.16 Tears Up.

    • Isaac's tears have a 15% chance of causing a fear effect.

    • Feared enemies will run away from Isaac temporarily.

    • The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time.

      Type: Passive

      Item Pool: Item Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, item room, treasure room, item room pool

  • Mom's Purse

    ItemID: 139

    "More trinket room"

    • Isaac can now hold two trinkets at the same time

    • Allows you to pick up more trinkets while also holding The Tick

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Mom's Wig

    ItemID: 217

    "You feel itchy"

    • Isaac now has a chance to create friendly attack spiders everytime he fires a tear.

    • Can create up to a maximum of 5 spiders in the room at one time.

    • The Hive Mind item allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5.

    • The chance to create a spider is affected by your luck stat and at +10 Luck it will activate every time.

    • Heals you for 1 red heart when picked up.

      Type: Passive

      Item Pool: Item Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, item room, treasure room, item room pool

  • Mom's Underwear

    ItemID: 29

    "Range Up"

    • +5.25 Range Up

    • +0.5 Tear Height.

      Type: Passive

      Item Pool: Boss Room, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, boss room pool, boss room item,

  • Money = Power

    ItemID: 109

    "$$$ = DMG"

    • +0.04 Damage Up for every coin you currently have.

    • At 99 coins this item gives +3.96 Damage Up.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Mongo Baby

    ItemID: 322

    "Mongo friend"

    • A familiar that will follow Isaac and copy the effect of one of your other familiars.

    • If you don't have any other familiars, he will just shoot normal tears.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Monster Manual

    ItemID: 123

    "Temporary buddy generator"

    • When used, gives a random familiar for the rest of the room.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Monstro's Lung

    ItemID: 229

    "Charged attack"

    • Tears can now be charged and released in a shotgun style effect, much like Monstro's main attack.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool,

  • Monstro's Tooth

    ItemID: 86

    "Summon monstro"

    • When used, spawns a monstro which will jump on a random enemy in the room, dealing 120 damage.

    UNLOCK: Unlock this item by beating the Basement II for the first time.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Mr. Boom

    ItemID: 37

    "Reusable bomb buddy"

    • Drops a large bomb below the player which does 110 damage.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * boss rush pool, boss rush room, item room, treasure room, item room pool

  • Mr. Mega

    ItemID: 106

    "Blast damage"

    • +5 Bombs

    • Bombs now do 110 damage (+60, up from 50) and have a larger blast radius.

    • Can be found in the secret room.

    UNLOCK: Unlock this item by destroying 10 tinted rocks.

      Type: Passive

      Item Pool: Item Room, Secret Room

    * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, dungeon room, challenge room pool, blood challenge room, arena pool,

  • The Mulligan

    ItemID: 151

    "They grow inside"

    • Isaac has a random chance to spawn a blue fly when one of his tears hits an enemy.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

    • Blue Flies do 2.0x of Isaac's damage.

    • The chance to activate this effect is not changed with your Luck stat.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Mutant Spider

    Special item

    ItemID: 153

    "Quad Shot"

    • Tears now shoot 4 at a time (Quad Shot)

    • Tears Down significantly (Tear delay * 2.1 + 3).

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • My Little Unicorn

    ItemID: 77

    "Temporary badass"

    • Gives Isaac temporary invincibility and allows him to do 40 contact damage to enemies per hit.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • My Reflection

    ItemID: 5

    "Boomerang tears"

    • Gives tears a boomerang effect.

    • +1.5 Range Up.

    • +0.6 Shot Speed Up.

    • +1 Tear Height.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Mysterious Liquid

    ItemID: 317

    "Toxic splash damage"

    • When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, mystery liquid,

  • Mystery Sack

    ItemID: 271

    "?"

    • A bag that follows Isaac and drops a random pickup every few rooms (Fixed in patch v1.04).

    • Can drop any kind of heart, coin, bomb or key.

    UNLOCK: Unlock this item by beating the Dark Room with Eden.

      Type: Passive, Familiar

      Item Pool: Item Room, Beggar, Secret Room

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, secret room pool, item room, treasure room, item room pool, mysterious sack, multiple sacks

  • The Nail

    ItemID: 83

    "Temporary demon form"

    • +0.7 Damage Up.

    • -0.18 Speed Down.

    • +1 Soul Heart

    • Gives you the ability to crush rocks by walking over them.

    • All the above effects are only active when the item is used.

    UNLOCK: Unlock this item by beating the Boss Rush with Azazel.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal

  • The Necronomicon

    ItemID: 35

    "Mass room damage"

    • Deals 40 damage to everything in the room when used.

    UNLOCK: Unlock this item by using 4 Death Cards.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Library, Secret Room, Devil Room

    * library pool, library room, book room pool, secret room pool, devil pool, devil room pool, devil deal

  • The Negative

    ItemID: 328

    "Fate chosen"

    • Damages all enemies in the room when hit down to 1/2 heart remaining.

    • Gives you access to the Dark Room floor.

    • When unlocked, is guaranteed to drop after the Mom's Foot boss fight.

    UNLOCK: Unlock this item by beating Satan in Sheol 5 times.

      Type: Passive

      Item Pool: None (Mom's foot boss only)

    * mom's foot, mom fight, mom boss, dark room

  • Notched Axe

    ItemID: 147

    "Rocks didn't stand a chance"

    • Each charge of this item allows Isaac to break all rocks, pots and secret room doors in the current room.

    • Cannot break the stone blocks which appear in the environment.

    • If Isaac is damaged while the effect is active, it will deactivate.

      Type: Active

      Recharge Time: 3 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, minecraft, notch, markus persson, minceraft, mojang

  • Number One

    ItemID: 6

    "Tears up"

    • Gives you a very high tear rate in exchange for a big range down.

    • +1.5 Tears Up.

    • -15.78 Range Down.

    • +0.45 Tear Height.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, mm sweet lemonade, urine,

  • Odd Mushroom (Thick)

    ItemID: 121

    "DMG up"

    • +1 Health Up.

    • +0.3 Damage Up.

    • +0.25 Range Up.

    • -0.1 Speed Down.

    • +0.5 Tear Height.

      Type: Passive

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • Odd Mushroom (Thin)

    ItemID: 120

    "Fire rate up"

    • Gives you a high rate of fire in exchange for a damage down.

    • +1.7 Tears Up.

    • +0.3 Speed Up.

    • Damage Down (damage * 0.9 - 0.4).

      Type: Passive

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • Old Bandage

    ItemID: 219

    "HP up"

    • +1 Health Up.

    • The given heart container is empty.

    • When you get hit, you will sometimes cause hearts to drop on the floor.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, the lost item pool

  • Ouija Board

    ItemID: 115

    "Spectral tears"

    • Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, luigi board, weeja board,

  • The Pact

    ItemID: 80

    "DMG + tears up"

    • +0.5 Damage Up.

    • +0.7 Tears Up.

    • +2 Soul Hearts.

      Type: Passive

      Item Pool: Devil Room, Curse Room

    * curse room pool, devil pool, devil room pool, devil deal, piece of paper, bloody paper, contract

  • Pageant Boy

    ItemID: 141

    "Ultimate grand supreme"

    • Spawns 7 random coins around Isaac on the floor.

    • Isaac wears a pink crown on his head.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, dtQt, dtphase, crown, nocrown, yescrown, diana, princezzxdiana

  • Pandora's Box

    ItemID: 297

    "? ?"

    • When used, this item will spawn a set of items or consumables based on which floor you are currently on.

    • Basement 1: 2 Soul hearts. Basement 2: 2 Bombs + 2 Keys.

    • Caves 1: 1 Boss Item. Caves 2: 1 Boss Item + 2 Soul Hearts.

    • Depths 1: 4 Soul hearts. Depths 2: 20 coins.

    • Womb 1: 2 Boss Items. Womb 2: Bible.

    • Sheol: 1 Devil Room Item + 1 Black Heart. Cathedral: 1 Angel Room Item + 1 Eternal Heart.

    • Dark Room: 1 Coin. Chest: 1 coin.

    • Pandora's Box considers XL floors to always be the first floor of a chapter.

    • This item disappears when used (One time use).

    UNLOCK: Unlock this item by beating the Dark Room with Lazarus.

      Type: Active

      Recharge Time: One time use

      Item Pool: Shop, Red Chest

    * red chest pool, red chest item pool, shop room pool, shop item pool, blue box

  • The Parasite

    ItemID: 104

    "Split shot"

    • Isaac's tears now split into two upon contact with enemies or the environment.

    • Tears that split off from the main tear do less damage (tear damage * 0.25).

    UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • The Peeper

    ItemID: 155

    "Plop!"

    • Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Pentagram

    ItemID: 51

    "DMG up"

    • +1.0 Damage Up.

    • Higher chance of a Devil Deal opening after the boss fight (Approximately +20% through testing).

      Type: Passive

      Item Pool: Boss Room, Curse Room, Devil Room

    * curse room pool, devil pool, devil room pool, devil deal, boss room pool, boss room item,

  • PhD

    ItemID: 75

    "Better pills"

    • All pills now have a positive or neutral effect.

    • Pills are identified before using them.

    • Drops one pill on pickup.

    • Heals for 2 full red hearts.

      Type: Passive

      Item Pool: Item Room, Shop

    * shop room pool, shop item pool, item room, treasure room, item room pool

  • Piggy Bank

    ItemID: 227

    "My life savings"

    • +3 Coins when picked up.

    • When you take damage, 1 or 2 coins will drop on the floor.

      Type: Passive

      Item Pool: Item Room, Shop

    * shop room pool, shop item pool, item room, treasure room, item room pool

  • Pisces

    ItemID: 309

    "Tears up + knockback shot"

    • +0.16 Tears Up.

    • Tears now have a knockback effect, which pushes enemies backwards.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • Placenta

    ItemID: 218

    "HP up + regen"

    • +1 Health Up.

    • Gives the player health regeneration over time.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, the lost item pool

  • Pinking Shears

    ItemID: 107

    "Cut and run"

    • Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, scissors, cutters, snip

  • The Polaroid

    ItemID: 327

    "Fate chosen"

    • Gives Isaac an invincibility shield for a few seconds when hit down to 1/2 heart remaining.

    • Gives you access to the Chest floor.

    • When unlocked, is guaranteed to drop after the Mom's Foot boss fight.

    UNLOCK: Unlock this item by beating Isaac in the Cathedral 5 times.

      Type: Passive

      Item Pool: None (Mom's foot boss only)

    *

  • Polyphemus

    Special item

    ItemID: 169

    "Mega tears"

    • High Damage Up - 2 * (damage + 4).

    • Tears Down significantly (Tear delay * 2.1 + 3).

    • If a tear kills an enemy, it continues to travel forward with the leftover damage.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, large eye, cyclops, one eye,

  • A Pony

    ItemID: 130

    "Flight + dash attack"

    • Allows Isaac to fly while the Pony is held.

    • Sets your speed stat to 1.5 if it isn't already that high.

    • When the active attack is used, Isaac will dash across the screen dealing 40 contact damage to anything he hits.

    • Drops from the Headless Horseman boss fight.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: None (Headless horseman only)

    * headless horseman, headless horsemen

  • The Poop

    ItemID: 36

    "Plop!"

    • Drops a poop on the floor.

    • Blue Baby starts with this item.

    • Can be placed next to a pit and exploded to make a bridge.

    • Can be placed over a broken red poop to overwrite it, causing it to no longer regenerate.

      Type: Active

      Recharge Time: 1 room

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Portable Slot

    ItemID: 177

    "Gamble 24/7"

    • Using the portable slot takes a coin and has a chance to give a pickup - Exactly the same as how the normal slot machines work.

      Type: Active

      Recharge Time: Instant

      Item Pool: Shop, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool,

  • Prayer Card

    ItemID: 146

    "Reusable eternity"

    • Gives Isaac an eternal heart when used.

    • Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Proptosis

    ItemID: 261

    "Short range mega tears"

    • Gives Isaac damage tears with a short range.

    • Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does.

    • Tear damage starts at double (+100%) and decreases over range to roughly (+30%).

    • Despite the very small tears visually, Proptosis is always a damage up at any range.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Punching Bag

    ItemID: 281

    "Scape goat"

    • Spawns a friendly Mulligan that walks around the room. Mulligan can be hit by enemy projectiles, making him a good shield.

    • Enemies will sometimes target the Mulligan if he is closer.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Pyro

    ItemID: 190

    "99 bombs"

    • +99 Bombs.

      Type: Passive

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • Pyromaniac

    Special item

    ItemID: 223

    "Hurts so good +5 bombs"

    • +5 Bombs

    • All explosions now heal Isaac for 1 heart instead of hurting him.

    • Isaac will also be healed by other sources such as Mom's leg stomp, Satan's leg stomp.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • A Quarter

    ItemID: 74

    "+25 coins"

    • +25 Coins

    • Has a very small chance to drop after destroying one of the pots that appear in the Basement and Cellar floors.

    UNLOCK: Unlock this item by beating Mom's Heart 8 times.

      Type: Passive

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • Rainbow Baby

    ItemID: 174

    "Random buddy"

    • A familiar the follows Isaac and fires random tears.

    • Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Raw Liver

    ItemID: 16

    "HP up"

    • +2 Health Up.

    • Full red heart heal.

      Type: Passive

      Item Pool: Secret Room

    * secret room pool, the lost item pool

  • Razor Blade

    ItemID: 126

    "Feel my pain"

    • When used, deals damage to Isaac in exchange for +1.2 damage up which lasts for the current room.

    UNLOCK: Unlock this item by beating Satan with Eve.

      Type: Active

      Recharge Time: Instant

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal, the lost item pool

  • Red Candle

    ItemID: 289

    "Flame on"

    • Allows you to fire a red flame infront of you, similar to the Blue Candle item, however the flame will stay for the current room.

    • Each flame deals 125 total damage.

    • The flame will shrink in size when deals damage to something and eventually disappear.

    UNLOCK: Unlock this item by donating 400 pennies to the Shop.

      Type: Active

      Recharge Time: Timed (A few seconds)

      Item Pool: Shop

    * shop room pool, shop item pool,

  • The Relic

    ItemID: 98

    "Soul generator"

    • A blue cross that follows Isaac and drops a soul heart every 4 rooms.

    UNLOCK: Unlock this item by beating the Isaac boss with Maggy.

      Type: Passive, Familiar

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Remote Detonator

    ItemID: 137

    "Remote bomb detonation"

    • +5 Bombs.

    • Bombs no longer automatically explode and will only do so when you activate the remote detonator.

    • Can be used to detonate Dr. Fetus bombs early.

      Type: Active

      Recharge Time: Instant

      Item Pool: Item Room, Shop

    * boss rush pool, boss rush room, shop room pool, shop item pool, item room, treasure room, item room pool

  • Robo-Baby

    ItemID: 95

    "Friends till the bzzzttt"

    • A familiar which follows Isaac and shoots lasers, similar to the Technology item.

    • Robo-Baby's laser is spectral and piercing (It will pass through rocks and objects in the environment)

    • Robo-Baby's lasers deal 3.5 damage per hit.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool, robo baby, robot baby,

  • Robo-Baby 2.0

    ItemID: 267

    "We worked out all the kinks"

    • A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight.

    • Robo-Baby 2.0's lasers deal 3.5 damage per hit.

    UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy).

      Type: Passive, Familiar

      Item Pool: Item Room

    * robo baby 2.0, item room, treasure room, item room pool

  • Roid Rage

    ItemID: 14

    "Speed and range up"

    • +0.6 Speed Up.

    • +5.25 Range Up.

    • +0.5 Shot Height.

      Type: Passive

      Item Pool: Item Room, Boss Room, Demon Beggar

    * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection,

  • Rosary

    ItemID: 72

    "Faith up"

    • +3 Soul Hearts.

    • Adds several instances of The Bible item into the Boss Room, Shop, Beggar, Secret Room, Gold Chest and Devil Pools.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Rotten Baby

    ItemID: 268

    "Infested friend"

    • A familiar which follows Isaac and spawns a blue flies.

    • Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used.

    • Blue Flies do 2.0x of Isaac's damage.

    • The Hive Mind item will cause Rotten Baby's flies to deal double damage.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Rotten Meat

    ItemID: 26

    "HP up"

    • +1 Health Up

      Type: Passive

      Item Pool: Boss Room, Beggar, Challenge Room

    * dungeon room, challenge room pool, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool

  • Rubber Cement

    ItemID: 221

    "Bouncing tears"

    • Isaac's tears now bounce off walls and objects in the environment, such as rocks and pots.

    • Allows tears to hit the same enemy multiple times.

    • If you also have Lost Contact, tears will bounce off enemy projectiles instead of being destroyed.

    UNLOCK: Unlock this item by beating Mom's heart 2 times.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Sack of Pennies

    ItemID: 94

    "Gives money"

    • A bag that floats around following Isaac and drops a random coin every 2 rooms.

    UNLOCK: Unlock this item by beating Isaac with Cain.

      Type: Passive, Familiar

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • Sacred Heart

    Special item

    ItemID: 182

    "Homing shots + DMG up"

    • Tears are now white, do a lot more damage and move slower across the screen with a homing effect.

    • Health Up.

    • Damage Up (damage * 2.3 + 1).

    • -0.4 Tears Down.

    • -0.25 Shot Speed Down.

    • +0.375 Range Up.

    • +0.75 Tear Height.

    • Full red heart heal.

      Type: Passive, Tear Modifier

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item

  • Sacrificial Dagger

    ItemID: 172

    "My fate protects me"

    • Gives Isaac an orbital knife that does 15 damage per tick on contact with enemies.

    • The Sacrificial Dagger does block shots in Rebirth, unlike the original game.

    • Synergises very well with invulnerability items such as Book of Shadows.

    UNLOCK: Unlock this item by beating the Chest with Eve.

      Type: Passive, Orbital

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Sad Bombs

    ItemID: 220

    "Tear blast +5 bombs"

    • +5 Bombs

    • Everytime a bomb explodes, it will release a circle of tears outwards, much like the Tammy's Head effect.

    • The tears caused by Sad Bombs are much larger and do a lot more damage than Isaac's normal tears.

      Type: Passive

      Item Pool: Item Room

    * boss rush pool, boss rush room, item room, treasure room, item room pool

  • The Sad Onion

    ItemID: 1

    "Tears up"

    • +0.7 Tears Up

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Safety Pin

    ItemID: 339

    "Evil up + range + shot speed"

    • +5.25 Range Up.

    • +0.16 Shot Speed Up.

    • +1 Black Heart.

    • +0.5 Tear Height.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Sagittarius

    ItemID: 306

    "Penetrative shot + speed up"

    • +0.2 Speed Up.

    • Tears now turn into arrow heads and pierce through enemies.

    • Tears do not travel through rocks with this item.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    *astrology, astronomy, item room, treasure room, item room pool, nys, notyoursagittarius

  • Samson's Chains

    ItemID: 321

    "The ol' ball and chain"

    • An iron ball and chain attached to Isaac, very similar to Guppy's Hairball that you can fling around to deal damage.

    • The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls.

    • Does not decrease your movement speed stat but will cause you to become slower due to its weight.

    UNLOCK: Unlock this item by beating Boss Rush with Samson.

      Type: Passive, Familiar

      Item Pool: Item Room, Secret Room

    * secret room pool, item room, treasure room, item room pool

  • The Satanic Bible

    ItemID: 292

    "Reusable evil"

    • When used, gives Isaac +1 Black Heart.

    • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

    UNLOCK: Unlock this item by beating the Isaac boss with Azazel.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room, Library, Devil Room

    * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, the lost item pool

  • Scapular

    ItemID: 142

    "You have been blessed"

    • Once per room when you are damaged down to half a heart, you gain 1 soul heart.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, the lost item pool

  • Scissors

    ItemID: 325

    "Lose your head"

    • Similar to the Pinking Shears, when used will cut your head from your body, however this item allows you to control Isaac's body.

    • Isaac's detached head will remain stationary and shoot tears in the direction you are firing.

    UNLOCK: Unlock this item by dying 100 times.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Scorpio

    ItemID: 305

    "Poison tears"

    • Isaac's tears turn bright green and always apply a poison effect to enemies which deals 4 or 6 damage per tick.

    • This is essentially a superior version of The Common Cold item.

    • Gives Dr. Fetus bombs a big increase in damage.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • Screw

    ItemID: 255

    "Tears + shot speed up"

    • +0.5 Tears Up

    • +0.2 Shot Speed Up

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Sharp plug

    ItemID: 205

    "Charge with blood"

    • When your spacebar item is out of charge, you can press spacebar to use it at the cost of 2 health.

    • This item only costs 1/2 a heart to use if you have The Wafer or the Cancer item.

    • The Sharp Plug will take health from Soul/Black hearts (if any) before taking red hearts.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool, the lost item pool

  • Shoop Da Whoop

    ItemID: 49

    "BLLLARRRRGGG!"

    • When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone.

    • Laser damage is based on your damage stat. One full laser deals your tear damage * 7 (Almost half as much as one Brimstone laser).

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Sissy Long Legs

    ItemID: 280

    "She loves you"

    • An adorable friendly blue spider that walks around the room laying other blue spiders which attack enemies.

    • Blue Spiders do 2.5x of Isaac's damage.

      Type: Passive, Familiar

      Item Pool: Item Room

    * item room, treasure room, item room pool, q t 3.14, dark bum, otp, damn it reddit

  • Sister Maggy

    ItemID: 67

    "Friends 'till the end"

    • A familiar which follows Isaac around and shoots blood tears that deal 3.5 damage.

      Type: Passive, Familiar

      Item Pool: Item Room, Devil Room

    * devil pool, devil room pool, devil deal, item room, treasure room, item room pool

  • Skatole

    ItemID: 9

    "Fly love"

    • All fly enemies are no longer aggressive towards Isaac.

    • Is only available from the shell game in the arcade.

    • Can be won from the arcade skull game.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive

      Item Pool: None (Arcade shell game only)

    * arcade, skull game,

  • Skeleton Key

    ItemID: 17

    "99 keys"

    • +99 Keys

      Type: Passive

      Item Pool: Secret Room

    * secret room pool,

  • The Small Rock

    ItemID: 90

    "DMG up"

    • +1.0 Damage Up.

    • Does not affect your tears or speed stats like it did in the original game.

    • Has a chance to drop when exploding a tinted rock.

    UNLOCK: Unlock this item by destroying 100 tinted rocks.

      Type: Passive

      Item Pool: None (Tinted rock only)

    * tinted rock, marked rock,

  • Smart Fly

    ItemID: 264

    "Revenge fly"

    • A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it.

    • If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital.

    • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

      Type: Passive, Familiar

      Item Pool: Item Room, Key Beggar

    * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool

  • SMB Super Fan

    ItemID: 189

    "All stats up"

    • Isaac turns red like Meatboy.

    • +1 Health Up.

    • +0.3 Damage Up.

    • +0.2 Tears Up.

    • +0.5 Range Up.

    • +0.2 Speed Up.

    • +1.0 Tear Height.

    • Full red heart heal.

    UNLOCK: Unlock this item by beating Challenge #14 (It's in the Cards).

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • A Snack

    ItemID: 346

    "HP up"

    • +1 Health Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, the lost item pool

  • The Soul

    ItemID: 335

    "I am all"

    • +2 Soul Hearts.

    • Enemy projectiles will now slowly curve away from Isaac and avoid hitting him.

    UNLOCK: Unlock this item by beating Dark Room with The Lost.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool

  • Soy Milk

    Special item

    ItemID: 330

    "DMG down + tears way up"

    • Very high Tears Up: (delay /4) - 2

    • -80% Damage Down.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Speed Ball

    ItemID: 143

    "Speed + shot speed up"

    • +0.3 Speed Up.

    • +0.2 Shot Speed Up.

      Type: Passive

      Item Pool: Item Room, Boss Room, Demon Beggar

    * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection,

  • Spelunker Hat

    ItemID: 91

    "See-through doors"

    • Reveals the location of the Secret room, playing a jingle when it is shown.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, spelunky

  • Spider Butt

    ItemID: 171

    "Mass enemy slowdown + damage"

    • Upon use, does 10 damage to all enemies in the room and gives them a slowing effect.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Spider Bite

    ItemID: 89

    "Slow effect"

    • Tears now have a chance of slowing enemies and their projectiles for 2.5 seconds.

    • The chance to slow enemies is affected by your luck stat and at +15 Luck it will activate every time.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Spiderbaby

    ItemID: 211

    "Spider revenge"

    • Creates friendly attack spiders when Isaac is damaged.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool

  • Spirit of the Night

    ItemID: 159

    "Scary"

    • Gives Isaac the ability to fly and spectral tears.

      Type: Passive

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal

  • Spoon Bender

    ItemID: 3

    "Homing shots"

    • Gives Isaac's tears a homing effect.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Squeezy

    ItemID: 196

    "Tears up"

    • +2 Soul Hearts.

    • +0.4 Tears Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, mr. squeezy, mr squeezy, cobaltstreak

  • Starter Deck

    ItemID: 251

    "Extra card room"

    • Isaac can now hold 2 tarot cards at once.

    • All future pill drops (including Mom's Coin Purse) will now instead become Tarot card drops.

    • An item only available in the Shop room.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Steam Sale

    ItemID: 64

    "50% off"

    • Items in the shop are now -50% off, rounded down to the nearest whole number.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Stem Cells

    ItemID: 176

    "HP up"

    • +1 Health Up.

    • +0.16 Shot Speed Up.

      Type: Passive

      Item Pool: Item Room, Boss Room

    * boss room pool, boss room item, item room, treasure room, item room pool

  • Steven

    ItemID: 50

    "DMG up"

    • +1 Damage Up.

    • Has a chance to drop from the Steven boss fight.

    UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss.

      Type: Passive

      Item Pool: None (Steven boss only)

    *

  • Stigmata

    ItemID: 138

    "DMG + HP up"

    • +1 Health Up.

    • +0.3 Damage Up.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Stop Watch

    Special item

    ItemID: 232

    "Let's slow this down a bit"

    • Gives a permanent slowing effect to all enemies in the room and their projectiles.

    • The slowing effect has a reduced effect against Brimstone lasers fired by enemies.

    UNLOCK: Unlock this item by donating 999 pennies to the Shop.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool, stopwatch

  • Strange Attractor

    ItemID: 315

    "Magnetic tears"

    • Enemies and pickups (keys, bombs etc.) are now magnetically attracted to Isaac's tears.

    • Can cause some enemies to have unpredictable movement.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Super Bandage

    ItemID: 92

    "+2 hearts"

    • +1 Health Up.

    • +2 Soul Hearts

    UNLOCK: Unlock this item by making a Super Bandage Girl.

      Type: Passive

      Item Pool: Item Room, Boss Room

    * boss room pool, boss room item, item room, treasure room, item room pool, the lost item pool

  • Synthoil

    ItemID: 345

    "DMG up + range"

    • +1.0 Damage Up.

    • +5.25 Range Up.

    • +0.5 Tear Height.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item, syringe

  • Tammy's Head

    ItemID: 38

    "Reusable tear burst"

    • Fires 10 tears in a circle around Isaac.

    • Each tear is equal to your damage stat + 25 flat damage.

    • Synergizes very well with most tear effects including tear modifiers like Mom's Knife and Brimstone.

      Type: Active

      Recharge Time: 1 room

      Item Pool: Gold Chest

    * golden chest pool, gold chest pool,

  • Taurus

    ItemID: 299

    "Speed down + rage is building"

    • -0.3 Speed Down.

    • While in a hostile room your speed raises at a rate of 0.065 per second.

    • When you hit a speed stat of 2.0, Isaac will gain the My Little Unicorn invincibility effect for a few seconds, increasing speed and allowing him to run into enemies to deal 40 contact damage per hit.

    • The time it takes for the effect to activate becomes shorter with a higher base Speed stat.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • Tech.5

    ItemID: 244

    "It's still being tested"

    • Gives Isaac a laser which is positioned in the centre of his head and will fire at random intervals while firing tears.

    • Each laser does damage equal to your current tear damage.

    • Luck has no effect on the rate at which Tech.5 fires and does not scale with items that increase your tears stat.

    UNLOCK: Unlock this item by beating Challenge #18 (The Host).

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * technology.5, item room, treasure room, item room pool

  • Technology

    ItemID: 68

    "Laser tears"

    • Isaac's tears are replaced with a laser that has unlimited range and can only fire at right angles.

    • Lasers travel through enemies but not rocks.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Technology 2

    ItemID: 152

    "Laser"

    • Isaac now also has a laser which fires continuously and does damage very rapidly.

    • -35% Damage Down.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Telepathy for Dummies

    ItemID: 192

    "Temporary psychic shot"

    • When used, Isaac gains homing shots for the current room.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room, Library

    * library pool, library room, book room pool, item room, treasure room, item room pool, yellow book how to

  • Teleport

    ItemID: 44

    "Teleport!"

    • Teleports Isaac to a random location on the map.

    • Has a very small chance to teleport you to the I AM ERROR room.

      Type: Active

      Recharge Time: 2 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, blue remote

  • There's Options

    ItemID: 249

    "More options"

    • Two items now spawn after beating a boss, however only one can be taken.

    • Appears in the shop pool.

    • Unlocked by donating to the donation machine in the shop.

    UNLOCK: Unlock this item by donating 50 pennies to the Shop.

      Type: Passive

      Item Pool: Shop

    * shop room pool, shop item pool,

  • Thunder Thighs

    ItemID: 314

    "HP + speed down + you feel strong"

    • +1 Health Up.

    • -0.4 Speed Down.

    • You can now break poop, rocks and skulls by walking over them.

    • Allows you to crush Red Poops and sometimes not take damage. However, If you also have flying you will always take damage.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Tiny Planet

    ItemID: 233

    "Orbiting tears + range up"

    • +7.0 Tear Height.

    • Tears now revolve around Isaac's Body at the distance of an attack fly.

      Type: Passive, Tear Modifier

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Toothpicks

    ItemID: 183

    "Tears + shot speed up"

    • +0.7 Tears Up.

    • +0.16 Shot Speed Up.

    • Does not increase your damage, simply makes your tears red.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Torn Photo

    ItemID: 341

    "Tears + shot speed up"

    • +0.7 Tears Up.

    • +0.16 Shot Speed Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Tough Love

    ItemID: 150

    "Tooth shot"

    • Isaac has a random chance to fire a tooth shot instead of a tear sometimes.

    • Teeth shots deal damage equal to your tear damage * 3.2.

    • The chance to fire a tooth is affected by your luck stat and at +9 Luck it will activate every time.

    • Synergizes well with some tear modifiers such as Ipecac, which causes it to do massive damage.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Transcendence

    ItemID: 20

    "We all float down here..."

    • Gives Isaac the ability to fly.

    UNLOCK: Unlock this item by beating Mom's Heart 3 times.

      Type: Passive

      Item Pool: Secret Room

    * secret room pool, the lost item pool

  • Treasure Map

    ItemID: 54

    "Full visible map"

    • Reveals the entire map for every floor not including the secret room locations.

    • Does not show the icons for any unknown rooms.

      Type: Passive

      Item Pool: Shop, Beggar

    * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool,

  • Trinity Shield

    ItemID: 243

    "You feel guarded"

    • Puts a shield in front of Isaac which blocks projectiles.

      Type: Passive

      Item Pool: Angel Room

    * angel room pool, god room pool, angel room item

  • Undefined

    ItemID: 324

    "Undefined"

    • Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance).

    • Allows you to loop through and the final floor infinitely. If you can get Undefined to teleport you to an I AM ERROR room, there will be a beam of light that takes you back to a new Chest/Dark Room floor with the same layout and refreshed rooms.

    UNLOCK: Unlock this item by beating Boss Rush with Eden.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Unicorn Stump

    ItemID: 298

    "You feel stumped"

    • When used, turns Isaac invincible and gains +0.28 speed for a few seconds.

    • You cannot fire tears while the stump is active.

    • Very similar to the My Little Unicorn item but does not deal contact damage.

    • When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active.

      Type: Active

      Recharge Time: 1 room

      Item Pool: Item Room

    * item room, treasure room, item room pool

  • Virgo

    ItemID: 303

    "You feel refreshed and protected"

    • A random chance when you take damage to get an invincibility shield for a few seconds (Similar to the Celtic Cross effect but more likely).

    • The chance to get an invincibility shield is affected by your luck stat and at +10 Luck it will activate every time you get hit.

    • Gives you the PhD effect, turning all negative pills into positive ones.

    • One of the twelve zodiac items available in the game.

      Type: Passive

      Item Pool: Item Room

    * astrology, astronomy, item room, treasure room, item room pool

  • The Virus

    ItemID: 13

    "Poison touch"

    • Deals poison damage on contact with enemies (Damage over time 4 or 6 per tick).

    • This item is not a speed down like it was in the original game.

      Type: Passive

      Item Pool: Item Room, Demon Beggar

    * demon beggar pool, demon judgement pool, devil beggar pool, item room, treasure room, item room pool, syringe, needle, injection, the lost item pool

  • The Wafer

    ItemID: 108

    "Damage resistance"

    • Lowers all damage taken by half rounding up to the nearest half-heart.

    • The Wafer becomes most effective in the Womb and beyond where enemies all deal a whole heart of damage.

    • The Wafer causes the Sharp Plug item to only cost 1/2 a heart per use.

      Type: Passive

      Item Pool: Item Room, Angel Room

    * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, communion, the lost item pool

  • We Need To Go Deeper

    ItemID: 84

    "Reusable level skip"

    • Spawns a trapdoor at Isaac's feet which allows him to travel to the next floor.

    • The trapdoor has a small chance (roughly 1/10) to become a Black Market.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: Secret Room, Devil Room

    * secret room pool, devil pool, devil room pool, devil deal

  • White Pony

    ItemID: 181

    "Flight + holy death"

    • Allows Isaac to fly while the White Pony is held.

    • Sets your speed stat to 1.5 if it isn't already that high.

    • Has a spacebar effect which is the same as the Crack the Sky item, which spawns white beams of light from the sky that deal 20 damage to enemies.

    • The charge of the spacebar attack deals 40 damage on contact with enemies.

    • Drops from the Conquest boss fight.

      Type: Active

      Recharge Time: 6 rooms

      Item Pool: None (Conquest boss only)

    *

  • Whore of Babylon

    ItemID: 122

    "Curse up"

    • When you only have half a heart remaining, you enter a curse state which adds +1.5 damage and +0.3 speed.

    • When playing as Eve, this item activates with one FULL heart remaining AND also removes her 0.75 damage multiplier, raising it up to 1.0.

    • One of Eve's starting items.

      Type: Passive

      Item Pool: Devil Room

    * devil pool, devil room pool, devil deal

  • Wire Coat Hanger

    ItemID: 32

    "Tears up"

    • +0.7 Tears Up.

    UNLOCK: Unlock this item by beating Mom's Heart 4 times.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • Wooden Spoon

    ItemID: 27

    "Speed up"

    • +0.3 Speed Up.

      Type: Passive

      Item Pool: Boss Room

    * boss room pool, boss room item,

  • X-Ray Vision

    ItemID: 76

    "I've seen everything"

    • Reveals the entrance to secret rooms and automatically opens the hole, removing the need for bombs to enter.

      Type: Passive

      Item Pool: Item Room

    * item room, treasure room, item room pool, xray vision, xray glasses

  • Yum Heart

    ItemID: 45

    "Reusable regeneration"

    • Heals Isaac for one whole red heart.

    • Maggy starts with this item.

      Type: Active

      Recharge Time: 4 rooms

      Item Pool: Item Room

    * item room, treasure room, item room pool, the lost item pool, maggy

  • Rebirth Trinkets

  • ???'s Soul

    "Imaginary friend"

    • Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac.

    UNLOCK: Unlock this item by beating the Dark Room with Blue Baby.

    *

  • AAA Battery

    "Trickle charge"

    • Lowers your spacebar item charge rate by 1.

    • Cannot lower the charge of your spacebar item below 1 room.

    • For example, you will now be able to use a 3 room charge item after 2 rooms instead.

    *

  • Ace of Spades

    "Luck of the draw"

    • Gives Isaac a higher chance to find Tarot cards after clearing a room or from chests.

    *

  • Bible Tract

    "Faith up"

    • Higher chance of eternal hearts.

    * , the lost item pool

  • Black Lipstick

    "Evil up"

    • Increases the chance for Black hearts to spawn.

    UNLOCK: Unlock this item by beating the Dark Room with Eve.

    * , the lost item pool

  • Bloody Penny

    "Wealth of health"

    • Everytime you pick up a penny, you have a chance to spawn a red heart on the floor.

    UNLOCK: Unlock this item by beating the Chest with Samson.

    * , the lost item pool

  • Broken Magnet

    "It kinda works"

    • Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance.

    • Does not attract other pickups like the full Magneto item does.

    *

  • Broken Ankh

    "Eternal life?"

    • Has a chance (roughly 20%) to respawn with 3 Soul hearts as Blue Baby when you die.

    UNLOCK: Unlock this item by beating Satan with Lazarus.

    *

  • Broken Remote

    "It's broken"

    • Does the teleport effect every time you use your current spacebar item.

    • Can be used infinitely every room if you have Guppy's Paw and no red heart containers (Can be exploited to get to the boss room without clearing any other rooms).

    *

  • Burnt Penny

    "Wealth of chaos"

    • Everytime you pick up a coin, you have a chance to spawn a bomb on the floor.

    UNLOCK: Unlock this item by beating Challenge #13 (Beans!).

    *

  • Butt Penny

    "Wealth of gas"

    • Everytime you pick up a coin, you fart.

    *

  • Cain's Eye

    "May you see your destination

    • Gives a 25% chance to reveal map icons at the start of a new floor (The same effect as the Compass).

    UNLOCK: Unlock this item by beating the Chest with Cain.

    *

  • Callus

    "Your feet feel stronger"

    • Isaac no longer takes damage from walking over spikes and blood creep while this trinket is held.

    * , the lost item pool

  • Cancer

    "Yay, cancer!"

    • -2 Tear Delay (Tears Up).

    • The fire rate increase is applied in such a way that the higher your tear stat is, the more effective Cancer is.

    • Breaks the normal fire rate cap, allowing you to fire faster than the normal maximum.

    *

  • Cartridge

    "I remember these"

    • When Isaac takes damage, there is a chance he will gain the Gamekid effect, turning him invincible and dealing contact damage to any enemies he touches.

    • The chance to activate the invincibility effect is affected by your luck stat and at +38 Luck it will activate every time you get hit.

    * , the lost item pool

  • Child's Heart

    "It calls out to its brothers"

    • Gives Isaac a higher chance to find hearts from drops after clearing a room and from chests.

    * , the lost item pool

  • Counterfeit Penny

    "Wealth of wealth"

    • When picking up a coin, you have a chance to automatically gain one more coin.

    UNLOCK: Unlock this item by playing the shell game in the arcade 100 times.

    *

  • Cursed Skull

    "Cursed?"

    • When you take damage while on 1/2 a heart, you are teleported back to the previous room.

    * , the lost item pool

  • Curved Horn

    "DMG up"

    • +2 Damage Up

    UNLOCK: Unlock this item by beating the Dark Room with Judas.

    *

  • Daemon's Tail

    "Evil up"

    • When Daemon's Tail is held, most future Heart drop will be rerolled into something else, with a certain chance to be rerolled into a Black Heart.

    • Every type of heart will be affected (except for hearts spawned in Super Secret Rooms) and causes Mitre, Bible Tract, Mom's Pearl to become useless.

    • Upon entering a new room that already has hearts on the ground, they will all be converted into Black Hearts.

    • Hearts that spawn after clearing a room, opening a chest or playing a slot machine/beggar will be re-rolled into another possible pickup that could appear. This essentially means you are sacrificing your heart drops for a higher chance of all other pickups

    UNLOCK: Unlock this item by beating Satan with Azazel.

    *

  • Eve's Bird Foot

    "Revenge from beyond"

    • When you kill an enemy, you have a chance to spawn a transparent Dead Bird familiar.

    UNLOCK: Unlock this item by beating the Isaac boss with Eve.

    *

  • Fish Head

    "It stinks"

    • Everytime Isaac takes damage, one blue fly will spawn.

    * , the lost item pool

  • Flat Penny

    "Wealth of answers"

    • Everytime you pick up a coin, you have a chance to spawn a key.

    *

  • Flat Worm

    "Blub blub!"

    • Tears become flat and disc shaped giving them a larger hitbox.

    • Higher knockback effect with your tears.

    *

  • Goat Hoof

    "Speed up"

    • +0.15 Speed Up.

    *

  • Hook Worm

    "Zip zoop!"

    • Tears now move forwards at right angles, shifting left and right across the room.

    • Increases your range stat by +10.0 while held but due to the fire pattern, your tears travel a similar distance to normal.

    *

  • Isaac's Fork

    "Consume thy enemy"

    • After clearing a room, you have a chance to heal for half a red heart.

    *, the lost item pool

  • Isaac's Head

    "Dead friend"

    • While held, this trinket gives Isaac a familiar that shoots normal tears that deal 3.5 damage.

    UNLOCK: Unlock this item by beating the Boss Rush with Isaac.

    *

  • Judas' Tongue

    "Payment received"

    • Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart.

    UNLOCK: Unlock this item by beating Satan with Judas.

    * , the lost item pool

  • The Left Hand

    "The left hand path reaps dark rewards"

    • Replaces chest spawns with red chests.

    UNLOCK: Unlock this item by beating Ultra Pride.

    * northernlion, drop the left hand

  • Liberty Cap

    "Touch fuzzy, get dizzy!"

    • While held, this trinket gives a random mushroom effect each room

    • Possible mushrooms include: Mini Mush, Odd Mushroom (Thin), Odd Mushroom (Thick), The Compass.

    *

  • Lucky Rock

    "There's something inside"

    • Rocks now drop money when broken.

    UNLOCK: Unlock this item by destroying 100 rocks.

    *

  • Lucky Toe

    "Luck up!"

    • +1 Luck Up while held.

    UNLOCK: Unlock this item by blowing up 20 shop keepers (this includes the ones in the secret room).

    *

  • Maggy's Faith

    "Faith's reward"

    • At the start of a new floor, you get an eternal heart.

    UNLOCK: Unlock this item by beating the Dark Room with Maggy.

    * , the lost item pool

  • Match Stick

    "Tastes like burning"

    • Gives Isaac a higher chance to find bombs.

    *

  • A Missing Page

    "It glows with power"

    • When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect.

    • The chance to damage enemies is affected by your luck stat and at +50 or more Luck it will activate 50% of the time.

    * , the lost item pool

  • Missing Poster

    "???"

    • Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost'.

    UNLOCK: Unlock this item by beating Dark Room with Isaac.

    *

  • Mom's Pearl

    "It emanates purity"

    • Higher chance to find Soul Hearts.

    * , the lost item pool

  • Mom's Toenail

    "???"

    • Mom's Leg will now appear every 60 seconds and stomp down randomly in the room dealing 300 damage to enemies, similar to how Daddy Longlegs works but less frequent.

    • Be warned though, Mom's leg can also stomp and hurt Isaac too!

    *

  • Monkey's Paw

    "Wish granted"

    • When you reach half a heart of life remaining, a black heart will spawn.

    • After three black hearts have spawned, the trinket dissapears.

    * , the lost item pool

  • Mysterious Candy

    "Uh-oh!"

    • Causes Isaac to create poops randomly.

    *

  • Mysterious Paper

    "???"

    • Imitates the behaviours of some of the other 'paper' items/trinkets.

    • A Missing Page: When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect.

    • Has a chance to trigger the Polaroid or Negative effect every time you take damage with half a red heart or less.

    • Missing Poster: Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost'.

    • If held when you touch the chest after the Satan or Isaac fight and you don't have the relevant item to go to the next floor (Polaroid or Negative), you have a small chance to be taken there anyway.

    UNLOCK: Unlock this item by beating the Chest with Eden.

    *

  • Paper Clip

    "Master of lockpicking"

    • Allows you to unlock golden chests without needing a key.

    • Does not work on locked rooms.

    *

  • Petrified Poop

    "It feels lucky?"

    • While held, Isaac has a significantly higher chance to find drops when breaking poops.

    *

  • Pinky Eye

    "Poison shots"

    • Isaac's tears have a chance to poison enemies.

    • The poison effect leaves a damage over time, which deals 4 or 6 damage per tick.

    • The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time.

    *

  • Pulse Worm

    "Wub wub!"

    • Tears shrink and grow in size as they go across the room.

    • Does not appear to affect your damage and only the hitbox size of tears.

    *

  • Purple Heart

    "Challenge up"

    • Higher chance for champion enemies while held.

    *

  • Push Pin

    "Piercing shots"

    • Isaac now has a chance to make a spectral and piercing tear.

    • The chance to fire a piercing tear is affected by your luck stat and at +18 Luck it will activate every time.

    *

  • Red Patch

    "Your rage grows"

    • You have a chance when taking damage to gain +1.8 Damage Up for the rest of the room.

    * , the lost item pool

  • Ring Worm

    "Woop woop!"

    • While held, tears move in a spiral pattern across the screen at high speed.

    • Effectively increases your range due to the tear pattern.

    *

  • Rosary Bead

    "Faith up"

    • Increases your chances to find an Angel Room instead of a Devil Room.

    • Normally there is a 50%/50% chance of a Angel or Devil room with if a door spawns after the boss. The Rosary Bead changes this to a 75%/25% chance of an angel or devil room (respectively).

    *

  • Rusted Key

    "It feels lucky?"

    • Gives Isaac a higher chance to find keys and chests.

    *

  • Safety Cap

    "Don't swallow it"

    • Gives Isaac a higher chance to find pills.

    *

  • Samson's Lock

    "Your rage grows"

    • When you kill an enemy, you have a chance to get +0.5 damage up for the current room.

    UNLOCK: Unlock this item by beating the Dark Room with Samson.

    *

  • Store Credit

    "YES!

    • While this trinket is held, all items in the Shop cost 0 coins.

    • After buying any 0 cent item in the Shop, the trinket disappears.

    UNLOCK: Unlock this item by beating the Chest with Lazarus.

    *

  • Swallowed Penny

    "Gulp!"

    • Each time you get hit, you drop a coin or two.

    UNLOCK: Unlock this item by beating Challenge #15 (Slow Roll).

    * , the lost item pool

  • Tick

    "Well, that's not coming off"

    • When you enter a boss room, immediately remove 15% health from the boss and restore 1 red heart.

    • This trinket cannot be replaced or dropped, meaning you are unable to take any more trinkets unless you get the Mom's Purse item.

    *

  • Umbilical Cord

    "Fetal protection"

    • If you take damage which leaves you at 1/2 a heart, you gain a Little Steve familiar that follows you and shoots homing tears.

    * , the lost item pool

  • Whip Worm

    "Wooosh!"

    • +0.5 Shot Speed Up.

    • Your tears now whip across the room at a very high shot speed.

    *

  • Wiggle Worm

    "Wiggle wiggle!"

    • Tears now move in a wave fashion across the room.

    *

  • Consumables + Misc.

  • O - The Fool

    "Where your journey begins"

    • Teleports the player to the starting room of the current floor.

    *

  • I - The Magician

    "May you never miss your goal"

    • For the current room, tears now have the Spoon Bender effect, which allows them to curve towards enemies and gives them a purрle appearance.

    *

  • II - The High Priestess

    "Mother is watching you"

    • Summons Mom's foot which will stomp on a random enemy in the current room, dealing 300 damage.

    • If no enemies are in the current room, the foot will target Isaac (and do damage if it hits), however it can be used to break rocks.

    *

  • III - The Empress

    "May your rage bring power"

    • Gives the player the Whore of Babylon effect for the current room, increasing damage and speed.

    * speed up

  • IV - The Emperor

    "Challenge me!"

    • Teleports the player to the Boss room on the current floor.

    *

  • V - The Hierophant

    "Two prayers for the lost"

    • Spawns 2 Soul hearts on the floor.

    *, the lost item pool

  • VI - The Lovers

    "May you prosper and be in good health"

    • Spawns 2 red hearts on the floor.

    * , the lost item pool

  • VII - The Chariot

    "May nothing stand before you"

    • Grants the same effect as 'My Little Unicorn', which makes Isaac invincible and deal 40 contact damage to enemies per hit.

    *

  • VIII - Justice

    "May your future become balanced"

    • Spawns 1 bomb, 1 key, 1 coin, 1 heart, which can be random variants of each.

    *

  • IX - The Hermit

    "May you see what life has to offer"

    • Teleports the player to the Shop.

    • On or below the Womb, this acts as a random teleport, since there are no shops on those floors.

    *

  • X - Wheel of Fortune

    "Spin the wheel of destiny"

    • Spawns a Slot Machine or a Fortune Machine.

    *

  • XI - Strength

    "May your power bring rage"

    • Gives the player the Magic Mushroom effect, which increasing size and all stats by 1 for the current room.

    • If you use the Strength card with 12 heart containers, it will take you down to 11 when you leave the room.

    *

  • XII - The Hanged Man

    "May you find enlightenment"

    • Gives the player the flying effect for the current room, allowing the player to fly over obstacles in the room.

    • This card is useless if you have any item which allows you to permanently fly.

    * , the lost item pool

  • XIII - Death

    "Lay waste to all that oppose you"

    • Deals 40 damage to all enemies in the room in a similar style to the Necronomicon.

    *

  • XIV - Temperance

    "May you be pure in heart"

    • Spawns a Blood Donation Machine.

    * , the lost item pool

  • XV - The Devil

    "Revel in the power of your darkness"

    • Gives the Book of Belial effect for the current room, increasing damage.

    * damage up

  • XVI - The Tower

    "Destruction brings creation"

    • Spawns some troll bombs at random locations in the current room.

    • Each bomb deals 60 damage (normal bomb damage.

    *

  • XVII - The Stars

    "May you find what you desire"

    • Teleports the player to the Item Room.

    • On or below the Womb, this acts as a random teleport, since there are no item rooms on those floors.

    *

  • XVIII - The Moon

    "May you find all you have lost"

    • Teleports the player to the Secret Room.

    *

  • XIX - The Sun

    "May the light heal and enlighten you"

    • A card with three uses: A full heal, deals 100 damage to all enemies in the current room and reveals the entire map for the current floor (Treasure Map + The Compass).

    *

  • XX - Judgement

    "Judge lest ye be judged"

    • Spawns a beggar.

    • Has a chance to be a demon beggar.

    *

  • XXI - The World

    "Open your eyes and see"

    • Reveals the entire map and shows the icons for every room which has one.

    • This is completely useless if you currently have both the Treasure Map and The Compass.

    *

  • 2 of Spades

    "Item multiplier"

    • Doubles the number of keys you have.

    • If you have no keys, it gives you two.

    *

  • 2 of Clubs

    "Item multiplier"

    • Doubles the number of Bombs you have.

    • If you have no bombs, it gives you two.

    *

  • 2 of Hearts

    "Item multiplier"

    • Doubles your current red hearts up to full health.

    • If you have half a heart left, the card recovers your first two heart containers.

    • This card is useless for the Bluе Baby.

    * , the lost item pool

  • 2 of Diamonds

    "Item multiplier"

    • Doubles the number of coins you have.

    • If you have no coins, it gives you two.

    *

  • The Joker

    "???"

    • Teleports you to the Devil Deal Room on the current floor.

    *

  • Chaos Card

    "???"

    • A card which can be thrown as a projectile directly infront of Isaac, instantly killing anything it hits.

    • ...Yes that includes every boss in the game!

    • If thrown at a multi-phase boss like Satan, it will only kill that particular phase of the boss.

    • Will destroy rocks and poop in its path.

    • Can also be thrown against a door to open it (Doesn't work against Mega Satan's door).

    UNLOCK: Unlock this card by beating Challenge #9 (Demo Man).

    *

  • Credit Card

    "Charge it!"

    • When used, removes the price tag from all items in the current shop or devil deal, making everything free.

    • The effect of the Credit Card only lasts for the current room.

    UNLOCK: Unlock this card by beating Challenge #10 (Cursed!).

    *

  • Rules Card

    "???"

    • Displays a random cryptic message on the screen similar to the fortune machine ones. One of the following messages may show:

    • "Rooms may yield more than you expect"

    • "Some doors require a blessing. Carry them with you"

    • "The walls will harden over time. Time is the essence"

    • "Sleeping gatekeepers will need to be awoken with a loud sound"

    • A piece of paper is your guide"

    • Deny his gifts to attain your reward"

    • A dark market lies under your feet

    • Chub dislikes smoke!

    UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon).

    *

  • Card Against Humanity

    "Something stinks..."

    • When used, fills the entire room with poop!

    UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons).

    *

  • Suicide King

    "A true ending?"

    • When used, instantly kills you and spawns 10 pickup on the floor.

    • Each of the 10 things spawned can be any type of consumable or sometimes a pedestal item (up to a maximum of 3 pedestal items).

    • Any pedestal item created by Suicide King will be related to the room where it was used, meaning that using it in the Angel room will spawn Angel room items.

    UNLOCK: Unlock this card by beating Challenge #7 (Suicide King).

    *

  • Rune of Algiz

    "Resistance"

    • When used, gives you an invincibility effect which lasts for 30 seconds (much longer than normal invincibility effects).

    UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue).

    *

  • Rune of Ansuz

    "Vision"

    • When used, reveals the entire map including all the secret room locations and other icon rooms.

    UNLOCK: Unlock this card by beating Challenge #5 (The Tank).

    *

  • Rune of Berkano

    "Companionship"

    • Summons 3 blue friendly spiders and 3 blue flies.

    UNLOCK: Unlock this card by beating Challenge #20 (Purist).

    *

  • Rune of Dagaz

    "Purity"

    • Removes the curse which is in effect on the current floor.

    • Can also cure the effect of the Amnesia pill.

    • +1 Soul Heart.

    UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls).

    *

  • Rune of Ehwaz

    "Passage"

    • Creates a trapdoor on the floor (Same effect as We Need To Go Deeper).

    UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma).

    *

  • Rune of Hagalaz

    "Destruction"

    • When used, this rune will destroy all breakable objects in the current room, such as poop, rocks and skulls.

    UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black).

    *

  • Rune of Jera

    "Abundance"

    • When used this rune will double all pickups on the floor in the room.

    • Creates copies of pickups, even if you haven't purchased them yet.

    • Can be used to double the number of golden item chests in the first room of the final Chest floor.

    UNLOCK: Unlock this card by beating Challenge #2 (High Brow).

    *

  • Rune of Perthro

    "Change"

    • Rerolls all pedestal items in the current room (One time use of the D6).

    UNLOCK: Unlock this card by beating Challenge #6 (Solar System).

    *

  • Dice Rooms

    • 1 Dot - Rerolls all of your items. (Does not change your trinkets, pills or cards)

    • 2 Dot - Rerolls all pickups in the room. (D20 effect)

    • 3 Dot - Rerolls all pickups on the entire floor.

    • 4 Dot - Rerolls all pedestal items on the floor. (Does not roll your devil deal items)

    • 5 Dot - Reroll and restart the current floor (Forget Me Now effect).

    • 6 Dot - Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 rooms).

    *

  • Confused? Read the FAQ
    Balls of steel!